Three-dimensional model of the human platelet integrin alpha IIbbeta 3 based on electron cryomicroscopy and x-ray crystallography
about
Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrinsDisruption of the integrin alphaLbeta2 transmembrane domain interface by beta2 Thr-686 mutation activates alphaLbeta2 and promotes micro-clustering of the alphaL subunitsThe structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signallingStructure and function of the platelet integrin alphaIIbbeta3A specific interface between integrin transmembrane helices and affinity for ligandIntegrin bidirectional signaling: a molecular viewA structural hypothesis for the transition between bent and extended conformations of the leukocyte beta2 integrinsStructure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied ForcesStructure of an integrin IIb 3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activationThree-dimensional reconstruction of intact human integrin IIb 3: new implications for activation-dependent ligand bindingPlatelet integrin alpha(IIb)beta(3): activation mechanismsComputational prediction of atomic structures of helical membrane proteins aided by EM maps.Integrin alpha IIb beta 3 in a membrane environment remains the same height after Mn2+ activation when observed by cryoelectron tomography.Integrin conformational regulation: uncoupling extension/tail separation from changes in the head region by a multiresolution approach.Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins.Determination of N- and C-terminal borders of the transmembrane domain of integrin subunits.Integrin alphaIIbbeta3:ligand interactions are linked to binding-site remodeling.Recreation of the terminal events in physiological integrin activation.A push-pull mechanism for regulating integrin function.The final steps of integrin activation: the end gameTransmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (review).Integrin targeted therapeutics.Transmembrane and Juxtamembrane Structure of αL Integrin in Bicelles.Platelet receptors and their role in diseases.Multiscale simulations suggest a mechanism for integrin inside-out activation.Integrins, cations and ligands: making the connection.Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeuticsIntact alphaIIbbeta3 integrin is extended after activation as measured by solution X-ray scattering and electron microscopyInhibition of αIIbβ3 Ligand Binding by an αIIb Peptide that Clasps the Hybrid Domain to the βI Domain of β3.The Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological LigandThree-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin.Integrin structures and conformational signalingThree-Dimensional Structures of Full-Length, Membrane-Embedded Human α(IIb)β(3) Integrin ComplexesStructure and mechanics of integrin-based cell adhesion.Platelet integrins and immunoreceptors.αIIbβ3: structure and functionInteractions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activationOn the activation of integrin αIIbβ3: outside-in and inside-out pathways.Membrane-mediated structural transitions at the cytoplasmic face during integrin activation.Linking integrin conformation to function.
P2860
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P2860
Three-dimensional model of the human platelet integrin alpha IIbbeta 3 based on electron cryomicroscopy and x-ray crystallography
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Three-dimensional model of the ...... copy and x-ray crystallography
@ast
Three-dimensional model of the ...... copy and x-ray crystallography
@en
Three-dimensional model of the ...... copy and x-ray crystallography
@nl
type
label
Three-dimensional model of the ...... copy and x-ray crystallography
@ast
Three-dimensional model of the ...... copy and x-ray crystallography
@en
Three-dimensional model of the ...... copy and x-ray crystallography
@nl
prefLabel
Three-dimensional model of the ...... copy and x-ray crystallography
@ast
Three-dimensional model of the ...... copy and x-ray crystallography
@en
Three-dimensional model of the ...... copy and x-ray crystallography
@nl
P2860
P356
P1476
Three-dimensional model of the ...... copy and x-ray crystallography
@en
P2093
Brian D Adair
Mark Yeager
P2860
P304
14059-14064
P356
10.1073/PNAS.212498199
P407
P577
2002-10-18T00:00:00Z