The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy.
about
The RAB25 small GTPase determines aggressiveness of ovarian and breast cancersTargeting the mammalian target of rapamycin (mTOR): a new approach to treating cancerThe ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferationEssential function for ErbB3 in breast cancer proliferationNew targets for therapy in breast cancer: mammalian target of rapamycin (mTOR) antagonistsIncreased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2.FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell linesPTEN associates with the vault particles in HeLa cellsCritical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injuryVav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer.Phase I study of the mTOR inhibitor ridaforolimus and the HDAC inhibitor vorinostat in advanced renal cell carcinoma and other solid tumors.Expression profiling identifies genes involved in neoplastic transformation of serous ovarian cancer.Association between PTEN Gene IVS4 polymorphism and risk of cancer: a meta-analysisLinking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo.The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck.Global deletion of Trp53 reverts ovarian tumor phenotype of the germ cell-deficient white spotting variant (Wv) mice.Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcomeThe effect of leucine restriction on Akt/mTOR signaling in breast cancer cell lines in vitro and in vivo.Targeting signal transduction pathways in metastatic breast cancer: a comprehensive review.Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinomaInhibition of cell growth and induction of apoptosis in ovarian carcinoma cell lines CaOV3 and SKOV3 by natural withanolide Withaferin AA new crucial protein interaction element that targets the adenovirus E4-ORF1 oncoprotein to membrane vesiclesEstradiol abrogates apoptosis in breast cancer cells through inactivation of BAD: Ras-dependent nongenomic pathways requiring signaling through ERK and AktNovel agents in epithelial ovarian cancer.Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer.AXL is an essential factor and therapeutic target for metastatic ovarian cancerSelective PDZ protein-dependent stimulation of phosphatidylinositol 3-kinase by the adenovirus E4-ORF1 oncoprotein.Chemosensitisation by manganese superoxide dismutase inhibition is caspase-9 dependent and involves extracellular signal-regulated kinase 1/2.BRCC2 inhibits breast cancer cell growth and metastasis in vitro and in vivo via downregulating AKT pathway.Ubiquitin-specific protease 4 inhibits breast cancer cell growth through the upregulation of PDCD4AKT-independent PI3-K signaling in cancer - emerging role for SGK3.PI3K/AKT pathway regulates phosphorylation of steroid receptors, hormone independence and tumor differentiation in breast cancer.A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGFR.Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias.HER2 Ile655Val and PTEN IVS4 polymorphisms in patients with breast cancer.Gonadotropins regulate N-cadherin-mediated human ovarian surface epithelial cell survival at both post-translational and transcriptional levels through a cyclic AMP/protein kinase A pathway.
P2860
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P2860
The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy.
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The role of genetic abnormalit ...... nesis, prognosis, and therapy.
@ast
The role of genetic abnormalit ...... nesis, prognosis, and therapy.
@en
The role of genetic abnormalit ...... nesis, prognosis, and therapy.
@nl
type
label
The role of genetic abnormalit ...... nesis, prognosis, and therapy.
@ast
The role of genetic abnormalit ...... nesis, prognosis, and therapy.
@en
The role of genetic abnormalit ...... nesis, prognosis, and therapy.
@nl
prefLabel
The role of genetic abnormalit ...... nesis, prognosis, and therapy.
@ast
The role of genetic abnormalit ...... nesis, prognosis, and therapy.
@en
The role of genetic abnormalit ...... nesis, prognosis, and therapy.
@nl
P2093
P1433
P1476
The role of genetic abnormalit ...... nesis, prognosis, and therapy.
@en
P2093
K Siminovitch
P304
P356
10.1016/S0093-7754(01)90290-8
P433
5 Suppl 16
P577
2001-10-01T00:00:00Z