Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with other mammalian bombesin receptors.
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International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease statesBombesin-related peptides and their receptors: recent advances in their role in physiology and disease statesInsights into bombesin receptors and ligands: Highlighting recent advancesThe Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsIsolation, identification and biological activity of gastrin-releasing peptide 1-46 (oGRP 1-46), the primary GRP gene-derived peptide product of the pregnant ovine endometrium.Systematic optimization of a lead-structure identities for a selective short peptide agonist for the human orphan receptor BRS-3.Tyrosine 220 in the 5th transmembrane domain of the neuromedin B receptor is critical for the high selectivity of the peptoid antagonist PD168368.Rational design of a peptide agonist that interacts selectively with the orphan receptor, bombesin receptor subtype 3.Bombesin receptor subtype 3 as a potential target for obesity and diabetes.Novel chiral-diazepines function as specific, selective receptor agonists with variable coupling and species variability in human, mouse and rat BRS-3 receptor cells.Pharmacology of putative selective hBRS-3 receptor agonists for human bombesin receptors (BnR): affinities, potencies and selectivity in multiple native and BnR transfected cells.Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon.Evolution of bombesin conjugates for targeted PET imaging of tumors.Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3.Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor.Bombesin receptor-mediated imaging and cytotoxicity: review and current statusBombesin receptor subtype-3 agonists stimulate the growth of lung cancer cells and increase EGF receptor tyrosine phosphorylation.Pharmacology and selectivity of various natural and synthetic bombesin related peptide agonists for human and rat bombesin receptors differs.Effect of bombesin receptor subtype-3 and its synthetic agonist on signaling, glucose transport and metabolism in myocytes from patients with obesity and type 2 diabetes.ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth.Gastrin releasing peptide receptor expression is decreased in patients with Crohn's disease but not in ulcerative colitis.Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: purification of peptide E as a low-affinity ligand for mammalian bombesin receptors.The molecular basis for high affinity of a universal ligand for human bombesin receptor (BnR) family members.Factors contributing to obesity in bombesin receptor subtype-3-deficient micePre-clinical evaluation of eight DOTA coupled gastrin-releasing peptide receptor (GRP-R) ligands for in vivo targeting of receptor-expressing tumorsTargeted cytotoxic analogue of bombesin/gastrin-releasing peptide inhibits the growth of H-69 human small-cell lung carcinoma in nude mice.Bombesin-like receptor 3 regulates blood pressure and heart rate via a central sympathetic mechanismMolecular basis for agonist selectivity and activation of the orphan bombesin receptor subtype 3 receptor.Comparative pharmacology of bombesin receptor subtype-3, nonpeptide agonist MK-5046, a universal peptide agonist, and peptide antagonist Bantag-1 for human bombesin receptorsPharmacological characterization of a selective agonist for bombesin receptor subtype-3.Molecular basis for the selectivity of the mammalian bombesin peptide, neuromedin B, for its receptorCharacterization of putative GRP- and NMB-receptor antagonist's interaction with human receptors.Neuromedin B receptors regulate EGF receptor tyrosine phosphorylation in lung cancer cells.Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3.G protein-coupled receptor deorphanizations.Molecular imaging probes derived from natural peptides.A selective human bombesin receptor subtype-3 peptide agonist mediates CREB phosphorylation and transactivation.Bombesin marine toxin conjugates inhibit the growth of lung cancer cells.Identification and functional characterization of hemorphins VV-H-7 and LVV-H-7 as low-affinity agonists for the orphan bombesin receptor subtype 3.Discovery of potent and selective peptide agonists at the GRP-preferring bombesin receptor (BB2).
P2860
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P2860
Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with other mammalian bombesin receptors.
description
1997 nî lūn-bûn
@nan
1997 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Discovery of a high affinity r ...... mammalian bombesin receptors.
@ast
Discovery of a high affinity r ...... mammalian bombesin receptors.
@en
Discovery of a high affinity r ...... mammalian bombesin receptors.
@nl
type
label
Discovery of a high affinity r ...... mammalian bombesin receptors.
@ast
Discovery of a high affinity r ...... mammalian bombesin receptors.
@en
Discovery of a high affinity r ...... mammalian bombesin receptors.
@nl
prefLabel
Discovery of a high affinity r ...... mammalian bombesin receptors.
@ast
Discovery of a high affinity r ...... mammalian bombesin receptors.
@en
Discovery of a high affinity r ...... mammalian bombesin receptors.
@nl
P2093
P2860
P356
P1476
Discovery of a high affinity r ...... mammalian bombesin receptors.
@en
P2093
Pradhan TK
Searles RP
Spindel ER
P2860
P304
26062-26071
P356
10.1074/JBC.272.41.26062
P407
P577
1997-10-01T00:00:00Z