Three-dimensional solution structure of human interleukin-4 by multidimensional heteronuclear magnetic resonance spectroscopy.
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The structure of granulocyte-colony-stimulating factor and its relationship to other growth factorsThe existence of multiple conformers of interleukin-21 directs engineering of a superpotent analogueYoung Investigator Award Lecture. Structures of larger proteins, protein-ligand and protein-DNA complexes by multidimensional heteronuclear NMR.A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor.Manipulation and potentiation of antimycobacterial immunity using recombinant bacille Calmette-Guérin strains that secrete cytokinesIL-6 type cytokine receptor complexes: hexamer, tetramer or both?Mutagenesis in the C-terminal region of human interleukin 5 reveals a central patch for receptor alpha chain recognition.De novo design of an IL-4 antagonist and its structure at 1.9 A.Increased levels of alternatively spliced interleukin 4 (IL-4delta2) transcripts in peripheral blood mononuclear cells from patients with systemic sclerosisInter-species chimeras of leukaemia inhibitory factor define a major human receptor-binding determinantInterleukin-4 and interleukin-13: their similarities and discrepancies.Cytokine signalling and disease.A circularly permuted recombinant interleukin 4 toxin with increased activity.Nitric oxide and thiol redox regulation of Janus kinase activityA mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor alpha chainHematopoietic cytokines: similarities and differences in the structures, with implications for receptor binding.Interleukin-6: structure-function relationships.A potent human interleukin-4 antagonist stimulates the proliferation of murine cells expressing the human interleukin-4 binding chain.Structural insights into the common γ-chain family of cytokines and receptors from the interleukin-7 pathway.Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transductionRegulation of IL-4 Expression in Immunity and Diseases.Computational challenges for macromolecular structure determination by X-ray crystallography and solution NMR-spectroscopy.Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation.Two distinct functional sites of human interleukin 4 are identified by variants impaired in either receptor binding or receptor activation.Inhibition of GM-CSF production by recombinant human interleukin-4: negative regulator of hematopoiesis.Induced conformational change in human IL-4 upon binding of a signal-neutralizing DARPin.An automated method for modeling proteins on known templates using distance geometry.Homology model of human interferon-alpha 8 and its receptor complex.Structural characteristics and refolding of in vivo aggregated hyperthermophilic archaeon proteins.Mutational analysis of thrombopoietin for identification of receptor and neutralizing antibody sites.Epitope randomization redefines the functional role of glutamic acid 110 in interleukin-5 receptor activation.Assignment of the backbone 1H and 15N NMR resonances and secondary structure characterization of barstar.Molecular dynamics simulation of human interleukin-4: comparison with NMR data and effect of pH, counterions and force field on tertiary structure stability
P2860
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P2860
Three-dimensional solution structure of human interleukin-4 by multidimensional heteronuclear magnetic resonance spectroscopy.
description
1992 nî lūn-bûn
@nan
1992 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Three-dimensional solution str ...... gnetic resonance spectroscopy.
@ast
Three-dimensional solution str ...... gnetic resonance spectroscopy.
@en
Three-dimensional solution str ...... gnetic resonance spectroscopy.
@nl
type
label
Three-dimensional solution str ...... gnetic resonance spectroscopy.
@ast
Three-dimensional solution str ...... gnetic resonance spectroscopy.
@en
Three-dimensional solution str ...... gnetic resonance spectroscopy.
@nl
prefLabel
Three-dimensional solution str ...... gnetic resonance spectroscopy.
@ast
Three-dimensional solution str ...... gnetic resonance spectroscopy.
@en
Three-dimensional solution str ...... gnetic resonance spectroscopy.
@nl
P2093
P1433
P1476
Three-dimensional solution str ...... gnetic resonance spectroscopy.
@en
P2093
P304
P356
10.1126/SCIENCE.256.5064.1673
P407
P577
1992-06-01T00:00:00Z