Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation.
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Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signalingCrystal structure of a cytokine-binding region of gp130.Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasingStructure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound databaseBinding in the growth hormone receptor complex.STAT signaling in the pathogenesis and treatment of cancerHuman herpesvirus 8 interleukin-6 (vIL-6) signals through gp130 but has structural and receptor-binding properties distinct from those of human IL-6.Functional characterization of W147A: a high-affinity interleukin-11 antagonistInterleukin-6: structure-function relationships.The affinity-selection of a minibody polypeptide inhibitor of human interleukin-6.Engineering human interleukin-6 to obtain variants with strongly enhanced bioactivity.Development of an interleukin (IL) 6 receptor antagonist that inhibits IL-6-dependent growth of human myeloma cells.Rational design of a receptor super-antagonist of human interleukin-6.Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signallingMultiple myeloma: increasing evidence for a multistep transformation process.1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling.Modeled structure of the 75-kDa neurotrophin receptor.
P2860
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P2860
Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
@zh
1994年學術文章
@zh-hant
name
Generation of interleukin-6 re ...... mportant for gp130 activation.
@en
type
label
Generation of interleukin-6 re ...... mportant for gp130 activation.
@en
prefLabel
Generation of interleukin-6 re ...... mportant for gp130 activation.
@en
P2093
P2860
P1433
P1476
Generation of interleukin-6 re ...... mportant for gp130 activation.
@en
P2093
Altamura S
Ciapponi L
Paonessa G
Salvati AL
Toniatti C
P2860
P304
P407
P577
1994-03-01T00:00:00Z