A novel DNA topoisomerase I inhibitor with different mechanism from camptothecin induces G2/M phase cell cycle arrest to K562 cells.
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CFS-1686 causes cell cycle arrest at intra-S phase by interference of interaction of topoisomerase 1 with DNAWater-soluble oxoglaucine-Y(III), Dy(III) complexes: in vitro and in vivo anticancer activities by triggering DNA damage, leading to S phase arrest and apoptosis.Novel Nitrobenzazolo[3,2-a]quinolinium Salts Induce Cell Death through a Mechanism Involving DNA Damage, Cell Cycle Changes, and Mitochondrial PermeabilizationSynthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitorsTopoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms.Ethyl 9-fluoro-5,12-dioxo-5,12-dihydro-indolizino[2,3-g]quinoline-6-carboxyl-ate.DNA-Binding and Topoisomerase-I-Suppressing Activities of Novel Vanadium Compound Van-7A Novel Inhibitor of Topoisomerase I Is Selectively Toxic for a Subset of Non-Small Cell Lung Cancer Cell Lines.Transplantation of tissue-engineered human corneal endothelium in cat models3EZ,20Ac-ingenol, a catalytic inhibitor of topoisomerases, downregulates p-Akt and induces DSBs and apoptosis of DT40 cells.A Novel Spirooxindole Derivative Inhibits the Growth of Leishmania donovani Parasites both In Vitro and In Vivo by Targeting Type IB TopoisomeraseGuiding TRAIL to cancer cells through Kv10.1 potassium channel overcomes resistance to doxorubicin.Antitumor effects and mechanisms of Ganoderma extracts and spores oil.Gold(III) macrocycles: nucleotide-specific unconventional catalytic inhibitors of human topoisomerase I.Identification of cyclohexanone derivatives that act as catalytic inhibitors of topoisomerase I: effects on tamoxifen-resistant MCF-7 cancer cells.Neutral Porphyrin Derivative Exerts Anticancer Activity by Targeting Cellular Topoisomerase I (Top1) and Promotes Apoptotic Cell Death without Stabilizing Top1-DNA Cleavage Complexes.Design, synthesis and anticancer activity of oxoaporphine alkaloid derivatives.A novel oral camptothecin analog, gimatecan, exhibits superior antitumor efficacy than irinotecan toward esophageal squamous cell carcinoma in vitro and in vivo.
P2860
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P2860
A novel DNA topoisomerase I inhibitor with different mechanism from camptothecin induces G2/M phase cell cycle arrest to K562 cells.
description
2010 nî lūn-bûn
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2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年學術文章
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name
A novel DNA topoisomerase I in ...... ll cycle arrest to K562 cells.
@ast
A novel DNA topoisomerase I in ...... ll cycle arrest to K562 cells.
@en
A novel DNA topoisomerase I in ...... ll cycle arrest to K562 cells.
@nl
type
label
A novel DNA topoisomerase I in ...... ll cycle arrest to K562 cells.
@ast
A novel DNA topoisomerase I in ...... ll cycle arrest to K562 cells.
@en
A novel DNA topoisomerase I in ...... ll cycle arrest to K562 cells.
@nl
prefLabel
A novel DNA topoisomerase I in ...... ll cycle arrest to K562 cells.
@ast
A novel DNA topoisomerase I in ...... ll cycle arrest to K562 cells.
@en
A novel DNA topoisomerase I in ...... ll cycle arrest to K562 cells.
@nl
P2093
P2860
P356
P1433
P1476
A novel DNA topoisomerase I in ...... ll cycle arrest to K562 cells.
@en
P2093
Keli Agama
Lian-Quan Gu
Lin-Kun An
Zhi-Shu Huang
P2860
P304
10131-10136
P356
10.1021/BI1009419
P407
P50
P577
2010-11-08T00:00:00Z