Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.
about
hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathwayscbl-3: a new mammalian cbl family proteinRegulatory and signaling properties of the Vav family3D structure of Syk kinase determined by single-particle electron microscopyNovel recognition mode between Vav and Grb2 SH3 domainscbl-b inhibits epidermal growth factor receptor signalingRegulation of Cbl molecular interactions by the co-receptor molecule CD43 in human T cellsLigand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7Cbl negatively regulates JNK activation and cell deathDynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding.Cbl-b is a novel physiologic regulator of glycoprotein VI-dependent platelet activation.A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.E3 ubiquitin ligase Cbl-b in innate and adaptive immunity.Differential expression and signaling of CBL and CBL-B in BCR/ABL transformed cells.Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity.Cbl: many adaptations to regulate protein tyrosine kinases.Beyond the RING: CBL proteins as multivalent adapters.Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family.Understanding Rho/Rac biology in T-cells using animal models.Recruitment of Cbl-b to B cell antigen receptor couples antigen recognition to Toll-like receptor 9 activation in late endosomes.The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity.c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading.c-Cbl tyrosine kinase-binding domain mutant G306E abolishes the interaction of c-Cbl with CD38 and fails to promote retinoic acid-induced cell differentiation and G0 arrestThe proto-oncogene c-Cbl is a positive regulator of Met-induced MAP kinase activation: a role for the adaptor protein Crk.CD43 regulates the threshold for T cell activation by targeting Cbl functions.Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins.Expression and function of Cbl-b in T cells from patients with systemic lupus erythematosus, and detection of the 2126 A/G Cblb gene polymorphism in the Mexican mestizo population.A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.Impaired T-cell development in the absence of Vav1 and Itk.Vav1: Friend and Foe of Cancer.Selective inhibition of Fcepsilon RI-mediated mast cell activation by a truncated variant of Cbl-b related to the rat model of type 1 diabetes mellitus.CBL-B is required for leukemogenesis mediated by BCR-ABL through negative regulation of bone marrow homing.
P2860
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P2860
Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.
description
1997 nî lūn-bûn
@nan
1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Cbl-b, a member of the Sli-1/c ...... N-terminal kinase activation.
@ast
Cbl-b, a member of the Sli-1/c ...... N-terminal kinase activation.
@en
Cbl-b, a member of the Sli-1/c ...... N-terminal kinase activation.
@nl
type
label
Cbl-b, a member of the Sli-1/c ...... N-terminal kinase activation.
@ast
Cbl-b, a member of the Sli-1/c ...... N-terminal kinase activation.
@en
Cbl-b, a member of the Sli-1/c ...... N-terminal kinase activation.
@nl
prefLabel
Cbl-b, a member of the Sli-1/c ...... N-terminal kinase activation.
@ast
Cbl-b, a member of the Sli-1/c ...... N-terminal kinase activation.
@en
Cbl-b, a member of the Sli-1/c ...... N-terminal kinase activation.
@nl
P2093
P356
P1433
P1476
Cbl-b, a member of the Sli-1/c ...... n N-terminal kinase activation
@en
P2093
M Barbacid
M López-Barahona
X R Bustelo
P2888
P304
P356
10.1038/SJ.ONC.1201430
P407
P577
1997-11-01T00:00:00Z
P5875
P6179
1018923531