Characterization of Asxl1, a murine homolog of Additional sex combs, and analysis of the Asx-like gene family.
about
Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor {gamma}ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category.Functional conservation of Asxl2, a murine homolog for the Drosophila enhancer of trithorax and polycomb group gene AsxLoss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemiaMouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesisSRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)Functional annotation of novel lineage-specific genes using co-expression and promoter analysisAdditional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in miceASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.Loss of Asxl2 leads to myeloid malignancies in miceThe HARE-HTH and associated domains: novel modules in the coordination of epigenetic DNA and protein modificationsThe BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer.Additional sex combs-like 2 is required for polycomb repressive complex 2 binding at select targetsDrosophila Cyclin G and epigenetic maintenance of gene expression during developmentAcquired mutations in ASXL1 in acute myeloid leukemia: prevalence and prognostic value.De novo dominant ASXL3 mutations alter H2A deubiquitination and transcription in Bainbridge-Ropers syndrome.A functionally conserved Polycomb response element from mouse HoxD complex responds to heterochromatin factors.Loss of Asxl1 leads to myelodysplastic syndrome-like disease in miceDynamics of ASXL1 mutation and other associated genetic alterations during disease progression in patients with primary myelodysplastic syndrome.Unraveling the molecular pathophysiology of myelodysplastic syndromes.Update on cytogenetic and molecular changes in myelodysplastic syndromes.The need for additional genetic markers for myelodysplastic syndrome stratification: what does the future hold for prognostication?Recent advances in understanding the molecular pathogenesis of myelodysplastic syndromes.Mutations in epigenetic modifiers in acute myeloid leukemia and their clinical utility.ASXL1 mutations in myeloid neoplasms: pathogenetic considerations, impact on clinical outcomes and survival.The Role of Additional Sex Combs-Like Proteins in Cancer.ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis.The oncocytic subtype is genetically distinct from other pancreatic intraductal papillary mucinous neoplasm subtypes.ASXL gain-of-function truncation mutants: defective and dysregulated forms of a natural ribosomal frameshifting product?ASXL1 mutations are infrequent in young patients with primary acute myeloid leukemia and their detection has a limited role in therapeutic risk stratification.Gain-of-function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies.Mutation analysis of ASXL1, CBL, DNMT3A, IDH1, IDH2, JAK2, MPL, NF1, SF3B1, SUZ12, and TET2 in myeloproliferative neoplasms.Acute pro-B-Cell lymphoblastic leukemia transformed from myelodysplastic syndrome with an ASXL1 missense mutation: A case report with literature review.ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFβ pathway genes through histone deacetylation
P2860
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P2860
Characterization of Asxl1, a murine homolog of Additional sex combs, and analysis of the Asx-like gene family.
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2006 nî lūn-bûn
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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2006 թվականի հունվարին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年论文
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name
Characterization of Asxl1, a m ...... s of the Asx-like gene family.
@ast
Characterization of Asxl1, a m ...... s of the Asx-like gene family.
@en
Characterization of Asxl1, a m ...... s of the Asx-like gene family.
@nl
type
label
Characterization of Asxl1, a m ...... s of the Asx-like gene family.
@ast
Characterization of Asxl1, a m ...... s of the Asx-like gene family.
@en
Characterization of Asxl1, a m ...... s of the Asx-like gene family.
@nl
prefLabel
Characterization of Asxl1, a m ...... s of the Asx-like gene family.
@ast
Characterization of Asxl1, a m ...... s of the Asx-like gene family.
@en
Characterization of Asxl1, a m ...... s of the Asx-like gene family.
@nl
P1433
P1476
Characterization of Asxl1, a m ...... s of the Asx-like gene family.
@en
P2093
Filippo Randazzo
Hugh W Brock
P304
P356
10.1016/J.GENE.2005.10.033
P407
P577
2006-01-18T00:00:00Z