Late sodium current in the pathophysiology of cardiovascular disease: consequences of sodium-calcium overload.
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The role of late I Na in development of cardiac arrhythmiasElectrophysiology of Heart Failure Using a Rabbit Model: From the Failing Myocyte to Ventricular Fibrillation.An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels.CELLULAR OPEN RESOURCE (COR): current status and future directions.Cardiac models in drug discovery and development: a review.Synergetic action of domain II and IV underlies persistent current generation in Nav1.3 as revealed by a tarantula toxin.A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current.Sodium overload due to a persistent current that attenuates the arrhythmogenic potential of a novel LQT3 mutation18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels.Cardiovascular drug discovery: a perspective from a research-based pharmaceutical company.Sodium channel biophysics, late sodium current and genetic arrhythmic syndromesBasal late sodium current is a significant contributor to the duration of action potential of guinea pig ventricular myocytes.Update on ranolazine in the management of angina.Systems pathology.Ranolazine: a new approach to treating an old problem.Intracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes.Calpain inhibition reduces amplitude and accelerates decay of the late sodium current in ventricular myocytes from dogs with chronic heart failurePost-transcriptional silencing of SCN1B and SCN2B genes modulates late sodium current in cardiac myocytes from normal dogs and dogs with chronic heart failure.Chronic heart failure slows late sodium current in human and canine ventricular myocytes: implications for repolarization variability.Signalling by protein phosphatases and drug development: a systems-centred view.A web portal for in-silico action potential predictionsChanges in Intracellular Na+ following Enhancement of Late Na+ Current in Virtual Human Ventricular Myocytes.Excavatolide B Modulates the Electrophysiological Characteristics and Calcium Homeostasis of Atrial Myocytes.Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.Late sodium current in failing heart: friend or foe?Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine.State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine.The Efficacy and Safety of Wenxin Keli in Patients with Frequent Premature Ventricular Contractions: A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Trial.Modulation of late sodium current by Ca2+, calmodulin, and CaMKII in normal and failing dog cardiomyocytes: similarities and differences.Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice.Ranolazine attenuated heightened plasma norepinephrine and B-Type natriuretic peptide-45 in improving cardiac function in rats with chronic ischemic heart failure.Molecular identity of the late sodium current in adult dog cardiomyocytes identified by Nav1.5 antisense inhibition.Late sodium current is a new therapeutic target to improve contractility and rhythm in failing heart.The cardiac persistent sodium current: an appealing therapeutic target?Re-evaluating the efficacy of beta-adrenergic agonists and antagonists in long QT-3 syndrome through computational modelling.Characterization and influence of cardiac background sodium current in the atrioventricular node.F 15845 inhibits persistent sodium current in the heart and prevents angina in animal modelsPathophysiology of the cardiac late Na current and its potential as a drug target.The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.Late Na+ current produced by human cardiac Na+ channel isoform Nav1.5 is modulated by its beta1 subunit.
P2860
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P2860
Late sodium current in the pathophysiology of cardiovascular disease: consequences of sodium-calcium overload.
description
2006 nî lūn-bûn
@nan
2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Late sodium current in the pat ...... es of sodium-calcium overload.
@ast
Late sodium current in the pat ...... es of sodium-calcium overload.
@en
Late sodium current in the pat ...... es of sodium-calcium overload.
@nl
type
label
Late sodium current in the pat ...... es of sodium-calcium overload.
@ast
Late sodium current in the pat ...... es of sodium-calcium overload.
@en
Late sodium current in the pat ...... es of sodium-calcium overload.
@nl
prefLabel
Late sodium current in the pat ...... es of sodium-calcium overload.
@ast
Late sodium current in the pat ...... es of sodium-calcium overload.
@en
Late sodium current in the pat ...... es of sodium-calcium overload.
@nl
P2860
P356
P1433
P1476
Late sodium current in the pat ...... es of sodium-calcium overload.
@en
P2093
P2860
P304
P356
10.1136/HRT.2005.078782
P407
P478
92 Suppl 4
P577
2006-07-01T00:00:00Z