F 15845 inhibits persistent sodium current in the heart and prevents angina in animal models
about
The role of late I Na in development of cardiac arrhythmiasThe persistent sodium current blocker riluzole is antiarrhythmic and anti-ischaemic in a pig model of acute myocardial infarction18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels.Riluzole protects against cardiac ischaemia and reperfusion damage via block of the persistent sodium current.Cardiac sodium channels and inherited electrophysiological disorders: an update on the pharmacotherapy.The late sodium current in heart failure: pathophysiology and clinical relevance.Functional Studies of Sodium Channels: From Target to Compound Identification.Molecular Pathophysiology of Congenital Long QT Syndrome.Selective inhibition of persistent sodium current by F 15845 prevents ischaemia-induced arrhythmias.Persistent (current) in the face of adversity ... a new class of cardiac anti-ischaemic compounds on the horizon?F 15845, a new blocker of the persistent sodium current prevents consequences of hypoxia in rat femoral artery.Riluzole reduces arrhythmias and myocardial damage induced by coronary occlusion in anaesthetized pigs.
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F 15845 inhibits persistent sodium current in the heart and prevents angina in animal models
description
article científic
@ca
article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 07 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
F 15845 inhibits persistent so ...... events angina in animal models
@en
F 15845 inhibits persistent so ...... vents angina in animal models.
@nl
type
label
F 15845 inhibits persistent so ...... events angina in animal models
@en
F 15845 inhibits persistent so ...... vents angina in animal models.
@nl
prefLabel
F 15845 inhibits persistent so ...... events angina in animal models
@en
F 15845 inhibits persistent so ...... vents angina in animal models.
@nl
P2093
P2860
P1476
F 15845 inhibits persistent so ...... events angina in animal models
@en
P2093
B Le Grand
R Létienne
Y Verscheure
P2860
P304
P356
10.1111/J.1476-5381.2008.00062.X
P407
P577
2009-01-07T00:00:00Z