Regulation of calcium release by interdomain interaction within ryanodine receptors.
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Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunctionIn cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin bindingDisease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interfaceCCDI: a new ligand that modulates mammalian type 1 ryanodine receptor (RyR1)Mg2+ activates the ryanodine receptor type 2 (RyR2) at intermediate Ca2+ concentrationsDynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptorStructural and functional characterization of ryanodine receptor-natrin toxin interactionCatecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.Imaging single cardiac ryanodine receptor Ca2+ fluxes in lipid bilayers.Characterization of a novel mutation in the cardiac ryanodine receptor that results in catecholaminergic polymorphic ventricular tachycardiaIncreased Ca2+ sensitivity of the ryanodine receptor mutant RyR2R4496C underlies catecholaminergic polymorphic ventricular tachycardia.Dysregulated sarcoplasmic reticulum calcium release: potential pharmacological target in cardiac disease.Localization of an NH(2)-terminal disease-causing mutation hot spot to the "clamp" region in the three-dimensional structure of the cardiac ryanodine receptor.Defective regulation of the ryanodine receptor induces hypertrophy in cardiomyocytes.Altered intracellular Ca2+ handling in heart failure.Shortened Ca2+ signaling refractoriness underlies cellular arrhythmogenesis in a postinfarction model of sudden cardiac death.Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure.Localization of a disease-associated mutation site in the three-dimensional structure of the cardiac muscle ryanodine receptorLocalization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor.Malignant hyperthermia: a pharmacogenetic disorder.Effects of conformational peptide probe DP4 on bidirectional signaling between DHPR and RyR1 calcium channels in voltage-clamped skeletal muscle fibers.Snapin, positive regulator of stimulation- induced Ca²⁺ release through RyR, is necessary for HIV-1 replication in T cells.Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia.Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damageOxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity.Interdomain cytoplasmic interactions govern the intracellular trafficking, gating, and modulation of the Kv2.1 channel.Carbonylation induces heterogeneity in cardiac ryanodine receptor function in diabetes mellitus.Ligand-dependent conformational changes in the clamp region of the cardiac ryanodine receptor.N-terminal and central segments of the type 1 ryanodine receptor mediate its interaction with FK506-binding proteinsCLIC2-RyR1 interaction and structural characterization by cryo-electron microscopy.Integrins protect cardiomyocytes from ischemia/reperfusion injury.Ryanodine receptor-mediated arrhythmias and sudden cardiac death.Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptorThree-dimensional localization of serine 2808, a phosphorylation site in cardiac ryanodine receptor.Calcium-induced calcium release in skeletal muscle.Ca handling during excitation-contraction coupling in heart failure.Investigating the inter-subunit/subdomain interactions and motions relevant to disease mutations in the N-terminal domain of ryanodine receptors by molecular dynamics simulation.Two regions of the ryanodine receptor calcium channel are involved in Ca(2+)-dependent inactivationThe emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantrolene.Activation of IP3 receptors requires an endogenous 1-8-14 calmodulin-binding motif.
P2860
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P2860
Regulation of calcium release by interdomain interaction within ryanodine receptors.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Regulation of calcium release by interdomain interaction within ryanodine receptors.
@ast
Regulation of calcium release by interdomain interaction within ryanodine receptors.
@en
Regulation of calcium release by interdomain interaction within ryanodine receptors.
@nl
type
label
Regulation of calcium release by interdomain interaction within ryanodine receptors.
@ast
Regulation of calcium release by interdomain interaction within ryanodine receptors.
@en
Regulation of calcium release by interdomain interaction within ryanodine receptors.
@nl
prefLabel
Regulation of calcium release by interdomain interaction within ryanodine receptors.
@ast
Regulation of calcium release by interdomain interaction within ryanodine receptors.
@en
Regulation of calcium release by interdomain interaction within ryanodine receptors.
@nl
P356
P1476
Regulation of calcium release by interdomain interaction within ryanodine receptors.
@en
P2093
Noriaki Ikemoto
Takeshi Yamamoto
P304
P356
10.2741/A803
P577
2002-03-01T00:00:00Z