Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia. - Wikidata - awgldk - TriplyDB

Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia.

Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia.

http://www.wikidata.org/entity/Q35156823

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Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death Channel Activity of Cardiac Ryanodine Receptors (RyR2) Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular Cardiomyocytes Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models Dantrolene suppresses spontaneous Ca2+ release without altering excitation-contraction coupling in cardiomyocytes of aged mice.Essential Role of Calmodulin in RyR Inhibition by Dantrolene.Carbonylation induces heterogeneity in cardiac ryanodine receptor function in diabetes mellitus.Abnormal Ca(2+) homeostasis, atrial arrhythmogenesis, and sinus node dysfunction in murine hearts modeling RyR2 modification Novel molecular targets for atrial fibrillation therapy.Inherited calcium channelopathies in the pathophysiology of arrhythmias.Themes and variations in ER/SR calcium release channels: structure and function.Ryanodine receptor calcium release channels: lessons from structure-function studies.Sinus node dysfunction in catecholaminergic polymorphic ventricular tachycardia: risk factor and potential therapeutic target?Structural and functional interactions within ryanodine receptor.Murine Electrophysiological Models of Cardiac Arrhythmogenesis.Ca2+ signaling in human induced pluripotent stem cell-derived cardiomyocytes (iPS-CM) from normal and catecholaminergic polymorphic ventricular tachycardia (CPVT)-afflicted subjects.The N-Terminal Region of the Ryanodine Receptor Affects Channel Activation.Luminal Ca2+ controls activation of the cardiac ryanodine receptor by ATP.Physiology and pathophysiology of excitation-contraction coupling: the functional role of ryanodine receptor.Ryanodine Receptor Structure and Function in Health and Disease.

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P2860

Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia.

http://www.wikidata.org/entity/Q35156823

description

2011 nî lūn-bûn

@nan

2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հուլիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Mutation-linked defective inte ...... rphic ventricular tachycardia.

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Mutation-linked defective inte ...... rphic ventricular tachycardia.

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type

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Mutation-linked defective inte ...... rphic ventricular tachycardia.

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Mutation-linked defective inte ...... rphic ventricular tachycardia.

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prefLabel

Mutation-linked defective inte ...... rphic ventricular tachycardia.

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Mutation-linked defective inte ...... rphic ventricular tachycardia.

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CIRCULATIONAHA.111.023259

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Mutation-linked defective inte ...... orphic ventricular tachycardia

@en

P2093

Akihiro Hino

http://www.w3.org/2001/XMLSchema#string

Hiroki Tateishi

http://www.w3.org/2001/XMLSchema#string

Hitoshi Uchinoumi

http://www.w3.org/2001/XMLSchema#string

Makoto Ono

http://www.w3.org/2001/XMLSchema#string

Masafumi Yano

http://www.w3.org/2001/XMLSchema#string

Masahiro Doi

http://www.w3.org/2001/XMLSchema#string

Masakazu Fukuda

http://www.w3.org/2001/XMLSchema#string

Masunori Matsuzaki

http://www.w3.org/2001/XMLSchema#string

Noriaki Ikemoto

http://www.w3.org/2001/XMLSchema#string

Shigeki Kobayashi

http://www.w3.org/2001/XMLSchema#string

P2860

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice.

Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.

Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor.

Localization of an NH(2)-terminal disease-causing mutation hot spot to the "clamp" region in the three-dimensional structure of the cardiac ryanodine receptor.

Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains.

Defective regulation of interdomain interactions within the ryanodine receptor plays a key role in the pathogenesis of heart failure.

Regulation of calcium release by interdomain interaction within ryanodine receptors.

Localization of a disease-associated mutation site in the three-dimensional structure of the cardiac muscle ryanodine receptor

Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.

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682-694

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scholarly article

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10.1161/CIRCULATIONAHA.111.023259

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6

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124

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Takeshi Suetomi

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2011-07-18T00:00:00Z

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21768539

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catecholaminergic polymorphic ventricular tachycardia

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3153588

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