Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes - Wikidata - awgldk - TriplyDB

Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes

Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes

http://www.wikidata.org/entity/Q34565013

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Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes type Aromatic-L-amino-acid decarboxylase, a pyridoxal phosphate-dependent enzyme, is a beta-cell autoantigen A type 1 diabetes-related protein from wheat (Triticum aestivum). cDNA clone of a wheat storage globulin, Glb1, linked to islet damage Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis Site-directed mutagenesis of K396R of the 65 kDa glutamic acid decarboxylase active site obliterates enzyme activity but not antibody binding.Approaches in type 1 diabetes research: A status report.Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression.Prevalence of autoantibodies to the 65- and 67-kD isoforms of glutamate decarboxylase in insulin-dependent diabetes mellitus Detection of pancreatic islet 64,000 M(r) autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase A comparison of the baseline metabolic profiles between Diabetes Prevention Trial-Type 1 and TrialNet Natural History Study participants.Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children.The use of FK 506 in new-onset type I diabetes in man.Molecular properties of HLA-DQ alleles conferring susceptibility to or protection from insulin-dependent diabetes mellitus: keys to the fate of islet beta-cells.Autoantigens in thyroid and islet autoimmunity: similarities and differences.A longitudinal study of GAD65 and ICA512 autoantibodies during the progression to type 1 diabetes in Diabetes Prevention Trial-Type 1 (DPT-1) participants.Antigen-specific therapeutic approaches in Type 1 diabetes Experimental autoimmune insulitis. Induction by T lymphocytes specific for a peptide of proinsulin.Type 1 diabetes as a model for prediction and diagnosis.The application of the diabetes prevention trial-type 1 risk score for identifying a preclinical state of type 1 diabetes.Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice.Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus.Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain Importance of persistent cellular and humoral immune changes before diabetes develops: prospective study of identical twins.Immunobiology of stiff-person syndrome.Human monoclonal islet cell antibodies from a patient with insulin-dependent diabetes mellitus reveal glutamate decarboxylase as the target antigen.Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice.Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetes Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes.Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. A population-based study. The Childhood Diabetes in Finland Study Group.Novel considerations on the antibody/autoantigen system in type I (insulin-dependent) diabetes mellitus.Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1.IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus.Inducing immune tolerance: a focus on Type 1 diabetes mellitus.Prediction and prevention of Type 1 diabetes mellitus.GAD-alum immunotherapy in Type 1 diabetes mellitus.Associations of human leukocyte antigens with autoimmune diseases: challenges in identifying the mechanism.Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity

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Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes

http://www.wikidata.org/entity/Q34565013

description

1987 nî lūn-bûn

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1987 թուականի Մարտին հրատարակուած գիտական յօդուած

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1987 թվականի մարտին հրատարակված գիտական հոդված

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1987年の論文

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1987年論文

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1987年論文

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1987年論文

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1987年論文

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1987年論文

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1987年论文

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name

Antibodies to a 64,000 Mr huma ...... of insulin-dependent diabetes

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Antibodies to a 64,000 Mr huma ...... of insulin-dependent diabetes

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Antibodies to a 64,000 Mr huma ...... of insulin-dependent diabetes

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Antibodies to a 64,000 Mr huma ...... of insulin-dependent diabetes

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Antibodies to a 64,000 Mr huma ...... of insulin-dependent diabetes

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Antibodies to a 64,000 Mr huma ...... of insulin-dependent diabetes

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Antibodies to a 64,000 Mr huma ...... of insulin-dependent diabetes

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Antibodies to a 64,000 Mr huma ...... of insulin-dependent diabetes

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Antibodies to a 64,000 Mr huma ...... of insulin-dependent diabetes

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Journal of Clinical Investigation

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Antibodies to a 64,000 Mr huma ...... of insulin-dependent diabetes

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P2093

C de Beaufort

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F Lindgren

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G Eisenbarth

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G J Bruining

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J K Kristensen

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J S Soeldner

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M Landin

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S Baekkeskov

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S Srikanta

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T Mandrup-Poulsen

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P2860

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

Phase separation of integral membrane proteins in Triton X-114 solution

Can future type I diabetes be predicted? A study in families of affected children.

Pre-type I diabetes. Linear loss of beta cell response to intravenous glucose.

Type I diabetes mellitus in monozygotic twins: chronic progressive beta cell dysfunction.

A major loss in islet mass and B-cell function precedes hyperglycemia in mice given multiple low doses of streptozotocin.

Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial.

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926-934

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scholarly article

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10.1172/JCI112903

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3

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79

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1987-03-01T00:00:00Z

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3546382

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424239

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