Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain
about
Lipid modifications of G proteins: alpha subunits are palmitoylated.Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brainIslet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigenPalmitoyl protein thioesterase-1 deficiency impairs synaptic vesicle recycling at nerve terminals, contributing to neuropathology in humans and miceThe synaptic vesicle-associated protein amphiphysin is the 128-kD autoantigen of Stiff-Man syndrome with breast cancerClinical and experimental studies of potentially pathogenic brain-directed autoantibodies: current knowledge and future directionsNovel diabetes autoantibodies and prediction of type 1 diabetesImogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patientAmino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65Targeting of the 67-kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65-kDa isoform of glutamic acid decarboxylasePhosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alphaStructural and functional analysis of cysteine residues in human glutamate decarboxylase 65 (GAD65) and GAD67.Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.Presence of diabetes autoantigens in extracellular vesicles derived from human islets.An AP-3-dependent mechanism drives synaptic-like microvesicle biogenesis in pancreatic islet beta-cells.Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clustersDemonstration of functional coupling between gamma -aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesiclesCalpain cleavage of brain glutamic acid decarboxylase 65 is pathological and impairs GABA neurotransmission.Pathogenic Roles of Glutamic Acid Decarboxylase 65 Autoantibodies in Cerebellar AtaxiasMice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol.Consensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias.In intact islets interstitial GABA activates GABA(A) receptors that generate tonic currents in α-cells.A membrane form of brain L-glutamate decarboxylase: identification, isolation, and its relation to insulin-dependent mellitus.Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neuronsIslet autoantigens: structure, function, localization, and regulation.GAD65 autoantibodies and its role as biomarker of Type 1 diabetes and Latent Autoimmune Diabetes in Adults (LADA).Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylaseAssociation of GAD-65, but not of GAD-67, with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region.Motifs and structural fold of the cofactor binding site of human glutamate decarboxylaseA combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65Protein palmitoylation in signal transduction of hematopoietic cells.Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus.The role of the synthetic enzyme GAD65 in the control of neuronal gamma-aminobutyric acid release.Antigen presentation of detergent-free glutamate decarboxylase (GAD65) is affected by human serum albumin as carrier protein.An islet-cell protein tyrosine phosphatase is a likely precursor to the 37-kDa autoantigen in type 1 diabetes: human and macaque sequences, tissue distribution, unique and shared epitopes, and predictive autoantibodies.Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes.Palmitoylation cycles and regulation of protein function (Review).GABA(A) receptor and glycine receptor activation by paracrine/autocrine release of endogenous agonists: more than a simple communication pathway.Vesicular and plasma membrane transporters for neurotransmitters.
P2860
Q24563070-1D584427-C4FD-4CD4-B604-BED6CF3DD676Q24602799-684F624A-388A-47DB-85FF-EB5775E19EB2Q24613961-30A1C651-0BF0-4938-999A-DC8617438E6BQ24644885-09E039C6-9517-407F-874E-8FE756961E12Q24680318-C200BD90-928E-496B-8F88-2E3D9E0B6147Q26824216-0644AC21-A602-4A43-8C76-424379031029Q27016130-48121C53-5CD0-4EA9-B092-508A2D02CA90Q28118623-201AEF9C-7FCD-4840-A4D2-D533FA8C1AF3Q28565866-590D8C7E-4208-4743-A9EF-4ADD4CCF92FAQ28582385-7DCC3E56-E298-412B-9184-333B9A57E1FFQ28582493-64DF4028-375C-4445-88E8-3CDC6C6289C1Q31160750-05CAEC83-B59D-416F-9A2B-3EBA870F6023Q33744544-EFEEDA44-E599-4A76-A9FB-F440E3902FE0Q33890308-F48F830F-700A-42D7-A8DA-406E7369D026Q33994381-A6CD01E1-2086-404D-981C-FFA234C11F48Q34111028-653E46DD-95BA-4A7E-A662-4FC63EDDE010Q34183366-F37E0019-1B22-4512-8EB7-29360F0AEBB0Q34200288-DC85B5E5-F539-461F-BBE5-8FE953BF9BF9Q34554924-83BFF130-8D8A-4E7E-A43A-5A7468A27BC0Q34572122-4E520B9D-026B-47FC-BC87-B47E21BFDF24Q34669020-D0A4BC94-C98C-468B-9014-D46766556882Q34796718-F53E8EBA-4262-408C-A1EA-6B4457209EB0Q34932648-63F448EE-F843-4009-9D88-8A8F3B5D9ACDQ35010483-75D33EF2-0A9F-4314-9B30-C721437BB127Q35554433-FA5C0E10-B858-46A7-91E5-9D7E901441E7Q36119378-F60F99A7-CECF-4FE5-ABBF-B605E1756E04Q36137876-6A098AE3-EB11-4DE1-AC27-4F8C1F7D3C3DQ36202374-8E193C46-D8DC-4209-9DEA-FE18E6A45BADQ36217722-31DFD353-DACB-463A-8F4B-9644802CBF52Q36280979-4652E3E1-AD18-4D90-8E7C-FC61F5D79982Q36324079-3D80F785-820F-407B-9DCB-E247281D7380Q36328401-C2355B88-7887-4850-BD2D-4CCE6B99D32EQ36363509-B09C65D7-C2AE-417E-8198-0F5F5C9066ECQ36563300-CA8A8B54-5FA4-49FB-9606-A3432CC43201Q36742048-4D022A5E-4719-469D-B138-4E7E94090EF9Q36853549-60F07FD5-3766-4783-A31A-53531EB42DA5Q37356382-F918960F-FFD8-422A-892A-4BEFFF5842F9Q37377694-1CAD381A-8F15-4FDA-B9E0-47F3D977A05FQ37872651-AEF11C28-3CF7-43BB-A189-FAA501853CFFQ37971367-CEE91686-F68F-4EBA-BED1-87F176309B02
P2860
Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Membrane anchoring of the auto ...... ion in the NH2-terminal domain
@ast
Membrane anchoring of the auto ...... ion in the NH2-terminal domain
@en
type
label
Membrane anchoring of the auto ...... ion in the NH2-terminal domain
@ast
Membrane anchoring of the auto ...... ion in the NH2-terminal domain
@en
prefLabel
Membrane anchoring of the auto ...... ion in the NH2-terminal domain
@ast
Membrane anchoring of the auto ...... ion in the NH2-terminal domain
@en
P2093
P2860
P356
P1476
Membrane anchoring of the auto ...... ion in the NH2-terminal domain
@en
P2093
H J Aanstoot
H Schierbeck
S Baekkeskov
S Christgau
P2860
P304
P356
10.1083/JCB.118.2.309
P407
P577
1992-07-01T00:00:00Z