Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase
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Long-lived plasma cells and memory B cells produce pathogenic anti-GAD65 autoantibodies in Stiff Person SyndromeUltrasensitive Antibody Detection by Agglutination-PCR (ADAP)Phosphorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alphaCofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasisDistinct antigenic features of linear epitopes at the N-terminus and C-terminus of 65 kDa glutamic acid decarboxylase (GAD65): implications for autoantigen modification during pathogenesis.An analysis of the cross-reactivity of autoantibodies to GAD65 and GAD67 in diabetes.Characterization of CD4+ T cells specific for glutamic acid decarboxylase (GAD65) and proinsulin in a patient with stiff-person syndrome but without type 1 diabetes.Two distinct mechanisms target GAD67 to vesicular pathways and presynaptic clustersGlutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children.Antibodies to inhibitory synaptic proteins in neurological syndromes associated with glutamic acid decarboxylase autoimmunity.Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neuronsRelative paradigms between autoantibodies in lupus and autoantibodies in cancer.Autoimmune diabetes: more than just one flavor?Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein.Detection of Antibodies Directed to the N-Terminal Region of GAD Is Dependent on Assay Format and Contributes to Differences in the Specificity of GAD Autoantibody Assays for Type 1 Diabetes.A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD65, distinguish stiff-man syndrome from insulin-dependent diabetes mellitus.Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes.Autoantibodies to tumor-associated antigens: reporters from the immune system.Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes.Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice.Autoimmunity and the pathogenesis of type 1 diabetes.Stiff-person syndrome: insights into a complex autoimmune disorder.Autoimmune Addison's disease. Analysis of autoantibody binding sites on human steroid 21-hydroxylase.The glutamate decarboxylase and 38KD autoantigens in type 1 diabetes: aspects of structure and epitope recognition.GAD, diabetes, and Stiff-Man syndrome: some progress and more questions.Autoantibodies in insulin-dependent diabetes mellitus.Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4.Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus.The hydrophilic isoform of glutamate decarboxylase, GAD67, is targeted to membranes and nerve terminals independent of dimerization with the hydrophobic membrane-anchored isoform, GAD65.Islet cell autoantigens in type 1 diabetes.Increased expression of GAD65 and GABA in pancreatic beta-cells impairs first-phase insulin secretion.A signal located within amino acids 1-27 of GAD65 is required for its targeting to the Golgi complex region.Identification of a dominant epitope of glutamic acid decarboxylase (GAD-65) recognized by autoantibodies in stiff-man syndromeSequence homology of the diabetes-associated autoantigen glutamate decarboxylase with coxsackie B4-2C protein and heat shock protein 60 mediates no molecular mimicry of autoantibodies.Preservation of enzyme activity and antigenicity after mutagenesis of the membrane anchoring domain of GAD65.GAD65 antibody isotypes and epitope recognition during the prediabetic process in siblings of children with type I diabetes.Optimized purification strategies for the elimination of non-specific products in the isolation of GAD65-specific monoclonal autoantibodies.Autoantibody epitopes to the smaller isoform of glutamate decarboxylase do not differ in Swedish and Japanese type 1 diabetes patients and may be associated with high-risk human leucocyte antigen class II alleles.VGLUT1 synapses and P-boutons on regenerating motoneurons after nerve crush.
P2860
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P2860
Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Autoreactive epitopes defined ...... orm of glutamate decarboxylase
@ast
Autoreactive epitopes defined ...... orm of glutamate decarboxylase
@en
type
label
Autoreactive epitopes defined ...... orm of glutamate decarboxylase
@ast
Autoreactive epitopes defined ...... orm of glutamate decarboxylase
@en
prefLabel
Autoreactive epitopes defined ...... orm of glutamate decarboxylase
@ast
Autoreactive epitopes defined ...... orm of glutamate decarboxylase
@en
P2093
P2860
P356
P1476
Autoreactive epitopes defined ...... orm of glutamate decarboxylase
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.7.2832
P407
P577
1993-04-01T00:00:00Z