Human monoclonal islet cell antibodies from a patient with insulin-dependent diabetes mellitus reveal glutamate decarboxylase as the target antigen.
about
Long-lived plasma cells and memory B cells produce pathogenic anti-GAD65 autoantibodies in Stiff Person SyndromeMapping autoantigen epitopes: molecular insights into autoantibody-associated disorders of the nervous systemCofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasisCharacterization of CD4+ T cells specific for glutamic acid decarboxylase (GAD65) and proinsulin in a patient with stiff-person syndrome but without type 1 diabetes.Prevalence of autoantibodies to the 65- and 67-kD isoforms of glutamate decarboxylase in insulin-dependent diabetes mellitusCellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetesAutoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylaseGAD autoantibody epitope pattern after GAD-alum treatment in children and adolescents with type 1 diabetes.WIN 54954 treatment of mice infected with a diabetogenic strain of group B coxsackievirusThe glutamate decarboxylase and 38KD autoantigens in type 1 diabetes: aspects of structure and epitope recognition.Modulation of antigen presentation by autoreactive B cell clones specific for GAD65 from a type I diabetic patient.Islet cell antigens in the prediction and prevention of insulin-dependent diabetes mellitus.Islet cell autoantigens in type 1 diabetes.Identification of a dominant epitope of glutamic acid decarboxylase (GAD-65) recognized by autoantibodies in stiff-man syndromeSequence homology of the diabetes-associated autoantigen glutamate decarboxylase with coxsackie B4-2C protein and heat shock protein 60 mediates no molecular mimicry of autoantibodies.Autoantibody epitopes to the smaller isoform of glutamate decarboxylase do not differ in Swedish and Japanese type 1 diabetes patients and may be associated with high-risk human leucocyte antigen class II alleles.
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P2860
Human monoclonal islet cell antibodies from a patient with insulin-dependent diabetes mellitus reveal glutamate decarboxylase as the target antigen.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on September 1992
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
@da
vědecký článek
@cs
name
Human monoclonal islet cell an ...... oxylase as the target antigen.
@en
Human monoclonal islet cell an ...... oxylase as the target antigen.
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type
label
Human monoclonal islet cell an ...... oxylase as the target antigen.
@en
Human monoclonal islet cell an ...... oxylase as the target antigen.
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prefLabel
Human monoclonal islet cell an ...... oxylase as the target antigen.
@en
Human monoclonal islet cell an ...... oxylase as the target antigen.
@nl
P2093
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Human monoclonal islet cell an ...... oxylase as the target antigen.
@en
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Eiermann TH
Kientsch-Engel R
Scherbaum WA
Thivolet C
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P304
P356
10.1073/PNAS.89.18.8467
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P577
1992-09-01T00:00:00Z