Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin. - Wikidata - awgldk - TriplyDB

Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin.

Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin.

http://www.wikidata.org/entity/Q34569800

about

A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expression Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals The human polycystin-2 protein represents an integral membrane protein with six membrane-spanning domains and intracellular N- and C-termini Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2alpha Polycystic kidney disease protein fibrocystin localizes to the mitotic spindle and regulates spindle bipolarity Autosomal dominant polycystic kidney disease: the last 3 years ARPKD and early manifestations of ADPKD: the original polycystic kidney disease and phenocopies Cilia/Ift protein and motor -related bone diseases and mouse models The ciliary protein cystin forms a regulatory complex with necdin to modulate Myc expression Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function Function and dynamics of PKD2 in Chlamydomonas reinhardtii flagella.CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease.Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence Polycystic kidney disease.A latent capacity of the C. elegans polycystins to disrupt sensory transduction is repressed by the single-pass ciliary membrane protein CWP-5.Structural interaction and functional regulation of polycystin-2 by filamin The nphp-2 and arl-13 genetic modules interact to regulate ciliogenesis and ciliary microtubule patterning in C. elegans.The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD).Incompletely penetrant PKD1 alleles mimic the renal manifestations of ARPKD.Filamin-a increases the stability and plasma membrane expression of polycystin-2.Polycystin-2 (TRPP2) Regulation by Ca(2+) Is Effected and Diversified by Actin-Binding Proteins Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia.A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between osm-3 and nphp-4.Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia.Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway.Biliary and pancreatic dysgenesis in mice harboring a mutation in Pkhd1.Syntaxin 5 regulates the endoplasmic reticulum channel-release properties of polycystin-2.Characterization of PKD protein-positive exosome-like vesicles.Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.Ciliary dysfunction in polycystic kidney disease: an emerging model with polarizing potential Function and regulation of TRPP2 at the plasma membrane.Polycystins and cellular Ca2+ signaling.Looking at the (w)hole: magnet resonance imaging in polycystic kidney disease.Strategies targeting cAMP signaling in the treatment of polycystic kidney disease.Polycystins and partners: proposed role in mechanosensitivity.Role of cilia in normal pancreas function and in diseased states.Tesevatinib ameliorates progression of polycystic kidney disease in rodent models of autosomal recessive polycystic kidney disease.Expression of polycystins and fibrocystin on primary cilia of lung cells.

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P2860

Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin.

http://www.wikidata.org/entity/Q34569800

description

2006 nî lūn-bûn

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2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Kinesin-2 mediates physical an ...... polycystin-2 and fibrocystin.

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Kinesin-2 mediates physical an ...... polycystin-2 and fibrocystin.

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Kinesin-2 mediates physical an ...... polycystin-2 and fibrocystin.

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type

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Kinesin-2 mediates physical an ...... polycystin-2 and fibrocystin.

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Kinesin-2 mediates physical an ...... polycystin-2 and fibrocystin.

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Kinesin-2 mediates physical an ...... polycystin-2 and fibrocystin.

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Kinesin-2 mediates physical an ...... polycystin-2 and fibrocystin.

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Kinesin-2 mediates physical an ...... polycystin-2 and fibrocystin.

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Kinesin-2 mediates physical an ...... polycystin-2 and fibrocystin.

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P1433

Human Molecular Genetics

P1476

Kinesin-2 mediates physical an ...... n polycystin-2 and fibrocystin

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P2093

Carl X Chen

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Guanqing Wu

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Guochun Li

http://www.w3.org/2001/XMLSchema#string

Horacio F Cantiello

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Qiang Li

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Richard Glynne

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Shaohua Wang

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Weiyi Mai

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Xiao-Qing Dai

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Xing-Zhen Chen

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P2860

Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein

Specific association of the gene product of PKD2 with the TRPC1 channel

The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton

Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel

The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein

Role of the kinesin-2 family protein, KIF3, during mitosis

PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2

Alpha-actinin associates with polycystin-2 and regulates its channel activity

Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium, and cytoplasm

The autosomal recessive polycystic kidney disease protein is localized to primary cilia, with concentration in the basal body area

P304

3280-3292

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scholarly article

P356

10.1093/HMG/DDL404

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22

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P478

15

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P50

Nicolas Montalbetti

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2006-09-28T00:00:00Z

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6787041

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P698

17008358

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