TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.
about
An emerging role for TOR signaling in mammalian tissue and stem cell physiologyTargeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapyRapamycin and mTOR kinase inhibitorsPotential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathwayRheb and mTOR regulate neuronal polarity through Rap1BIdentification of Sin1 as an essential TORC2 component required for complex formation and kinase activityRegulation of mTORC1 by PI3K signalingmTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic InterventionsScaling the Drosophila Wing: TOR-Dependent Target Gene Access by the Hippo Pathway Transducer Yorkie17ß-Estradiol regulates mTORC2 sensitivity to rapamycin in adaptive cardiac remodelingImpaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberinAn RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells.p27Kip1 localization depends on the tumor suppressor protein tuberin.PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.Systematic cloning and analysis of autophagy-related genes from the silkworm Bombyx mori.A second-site noncomplementation screen for modifiers of Rho1 signaling during imaginal disc morphogenesis in Drosophila.Reconstruction of the yeast protein-protein interaction network involved in nutrient sensing and global metabolic regulation.Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling.mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of actionThe complexes of mammalian target of rapamycin.A phosphatidylinositol 3-kinase/protein kinase B-independent activation of mammalian target of rapamycin signaling is sufficient to induce skeletal muscle hypertrophyDiet and energy-sensing inputs affect TorC1-mediated axon misrouting but not TorC2-directed synapse growth in a Drosophila model of tuberous sclerosis.The evolution of the TOR pathway and its role in cancer.Mechanistic target of rapamycin complex 1 expands Th17 and IL-4+ CD4-CD8- double-negative T cells and contracts regulatory T cells in systemic lupus erythematosus.Rheb1 is required for mTORC1 and myelination in postnatal brain developmentPI3K-mTORC1 attenuates stress response by inhibiting cap-independent Hsp70 translation.Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb.Frontier of epilepsy research - mTOR signaling pathway.Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function.Targeting Rb inactivation in cancers by synthetic lethality.AKT and TOR signaling set the pace of the circadian pacemaker.Akt inhibition promotes ABCA1-mediated cholesterol efflux to ApoA-I through suppressing mTORC1.Review series: TOR kinase complexes and cell migration.A standardized randomized 6-month aerobic exercise-training down-regulated pro-inflammatory genes, but up-regulated anti-inflammatory, neuron survival and axon growth-related genes.Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ΔRG mouse model of tuberous sclerosis complex.Leucine and histidine independently regulate milk protein synthesis in bovine mammary epithelial cells via mTOR signaling pathway.AMPK-mediated inhibition of mTOR kinase is circumvented during immediate-early times of human cytomegalovirus infection.TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growthLST8 regulates cell growth via target-of-rapamycin complex 2 (TORC2).Targeting TORC1/2 enhances sensitivity to EGFR inhibitors in head and neck cancer preclinical models.
P2860
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P2860
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.
description
2006 nî lūn-bûn
@nan
2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
name
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.
@ast
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.
@en
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.
@nl
type
label
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.
@ast
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.
@en
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.
@nl
prefLabel
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.
@ast
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.
@en
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.
@nl
P2093
P2860
P356
P1476
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity.
@en
P2093
Eunjung Kim
Kun-Liang Guan
P2860
P304
P356
10.1073/PNAS.0602282103
P407
P577
2006-04-20T00:00:00Z