IFN-alpha and bortezomib overcome Bcl-2 and Mcl-1 overexpression in melanoma cells by stimulating the extrinsic pathway of apoptosis
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Interferon alpha for the adjuvant treatment of cutaneous melanomaInterferon alpha for the adjuvant treatment of cutaneous melanomaNoxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cellsDeubiquitinases (DUBs) and DUB inhibitors: a patent reviewStructurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines.Use of a nanoporous biodegradable miniature device to regulate cytokine release for cancer treatmentImplementation of validated pharmacodynamic assays in multiple laboratories: challenges, successes, and limitations.The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activityA phase I trial of bortezomib and interferon-α-2b in metastatic melanoma.Preclinical evaluation of recombinant human IFNα2b-containing magnetoliposomes for treating hepatocellular carcinoma.PRMT5 is upregulated in malignant and metastatic melanoma and regulates expression of MITF and p27(Kip1.).Proteasome inhibition blocks NF-κB and ERK1/2 pathways, restores antigen expression, and sensitizes resistant human melanoma to TCR-engineered CTLsIL-12 enhances the antitumor actions of trastuzumab via NK cell IFN-γ production.Targeted immunotherapy using anti-CD138-interferon α fusion proteins and bortezomib results in synergistic protection against multiple myeloma.Curcumin induces proapoptotic effects against human melanoma cells and modulates the cellular response to immunotherapeutic cytokines.Bortezomib pre-treatment prolongs interferon-alpha-induced STAT1 phosphorylation in melanoma cellsInterferon α Induces the Apoptosis of Cervical Cancer HeLa Cells by Activating both the Intrinsic Mitochondrial Pathway and Endoplasmic Reticulum Stress-Induced Pathway.The combination of MLN2238 (ixazomib) with interferon-alpha results in enhanced cell death in melanoma.Potential usage of proteasome inhibitor bortezomib (Velcade, PS-341) in the treatment of metastatic melanoma: basic and clinical aspectsDevelopment of Proteasome Inhibitors as Therapeutic Drugs.A conditionally replicating adenovirus carrying interleukin-24 sensitizes melanoma cells to radiotherapy via apoptosis.Type I IFNs signaling and apoptosis resistance in glioblastoma cells.Molecular mechanism of MART-1+/A*0201+ human melanoma resistance to specific CTL-killing despite functional tumor-CTL interaction.Interleukin-29 binds to melanoma cells inducing Jak-STAT signal transduction and apoptosis.
P2860
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P2860
IFN-alpha and bortezomib overcome Bcl-2 and Mcl-1 overexpression in melanoma cells by stimulating the extrinsic pathway of apoptosis
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
IFN-alpha and bortezomib overc ...... extrinsic pathway of apoptosis
@ast
IFN-alpha and bortezomib overc ...... extrinsic pathway of apoptosis
@en
IFN-alpha and bortezomib overc ...... extrinsic pathway of apoptosis
@nl
type
label
IFN-alpha and bortezomib overc ...... extrinsic pathway of apoptosis
@ast
IFN-alpha and bortezomib overc ...... extrinsic pathway of apoptosis
@en
IFN-alpha and bortezomib overc ...... extrinsic pathway of apoptosis
@nl
prefLabel
IFN-alpha and bortezomib overc ...... extrinsic pathway of apoptosis
@ast
IFN-alpha and bortezomib overc ...... extrinsic pathway of apoptosis
@en
IFN-alpha and bortezomib overc ...... extrinsic pathway of apoptosis
@nl
P2093
P2860
P1433
P1476
IFN-alpha and bortezomib overc ...... extrinsic pathway of apoptosis
@en
P2093
Abhik Ray Chaudhury
Adrian Lewis
Denis C Guttridge
Ene T Raig
Erinn Hade
Gregory B Lesinski
Gregory Young
Katherine J Ladner
Kristan Guenterberg
Lloyd Brown
P2860
P304
P356
10.1158/0008-5472.CAN-08-0426
P407
P577
2008-10-01T00:00:00Z