20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation - Wikidata - awgldk - TriplyDB

20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation

20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation

http://www.wikidata.org/entity/Q34655960

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Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system New vitamin D analogs as potential therapeutics in melanoma Vitamin D derivatives enhance cytotoxic effects of H2O2 or cisplatin on human keratinocytes Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin 20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes.Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity.Novel vitamin D analogs as potential therapeutics: metabolism, toxicity profiling, and antiproliferative activity.RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D.Vitamin D supplementation during pregnancy: safety considerations in the design and interpretation of clinical trials.Vitamin D and the skin: Physiology and pathophysiology.Purified mouse CYP27B1 can hydroxylate 20,23-dihydroxyvitamin D3, producing 1alpha,20,23-trihydroxyvitamin D3, which has altered biological activity Sensing the environment: regulation of local and global homeostasis by the skin's neuroendocrine system.Key role of CRF in the skin stress response system.Neuroendocrinology of the skin: An overview and selective analysis Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc 20-Hydroxyvitamin D2 is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells.Expression of vitamin D receptor decreases during progression of pigmented skin lesions.Production of 22-hydroxy metabolites of vitamin d3 by cytochrome p450scc (CYP11A1) and analysis of their biological activities on skin cells Metabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1 Indications on the use of vitamin D and vitamin D metabolites in clinical phenotypes.Antitumor effects of vitamin D analogs on hamster and mouse melanoma cell lines in relation to melanin pigmentation.Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture.Isolation of All CD44 Transcripts in Human Epidermis and Regulation of Their Expression by Various Agents.Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland.In vivo evidence for a novel pathway of vitamin D₃ metabolism initiated by P450scc and modified by CYP27B1.Chemical Synthesis and Biological Activities of 20S,24S/R-Dihydroxyvitamin D3 Epimers and Their 1α-Hydroxyl Derivatives.On the role of skin in the regulation of local and systemic steroidogenic activities.Total synthesis of biologically active 20S-hydroxyvitamin D3.Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes 20S-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3, exhibits potent antifibrogenic activity in vivo Novel activities of CYP11A1 and their potential physiological significance.Hydroxylation of 20-hydroxyvitamin D3 by human CYP3A4.Hydroxylation of CYP11A1-derived products of vitamin D3 metabolism by human and mouse CYP27B1.Metabolism of 1alpha-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1alpha,20-dihydroxyvitamin D3.25-Hydroxyvitamin D and Parathyroid Hormone Levels Are Independently Associated with the Hemoglobin A1c Level of Korean Type 2 Diabetic Patients: The Dong-Gu Study.Cytochromes p450 and skin cancer: role of local endocrine pathways.The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism, including CYP11A1 in osteoblasts.Novel vitamin D photoproducts and their precursors in the skin.Design, Synthesis and Biological Activities of Novel Gemini 20S-Hydroxyvitamin D3 Analogs.In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland.

P2860

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P2860

20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation

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2008 nî lūn-bûn

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20-Hydroxyvitamin D3, a produc ...... s keratinocyte differentiation

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Blazej Zbytek

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Emily Jones

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Minh N Nguyen

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Zorica Janjetovic

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P2860

Resurrection of vitamin D deficiency and rickets

Functional activity of serotoninergic and melatoninergic systems expressed in the skin

Regulation of involucrin gene expression

A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin

Calcium and vitamin D. Diagnostics and therapeutics.

Vitamin D: A millenium perspective.

Photosynthesis of previtamin D3 in human skin and the physiologic consequences.

Calcium- and vitamin D-regulated keratinocyte differentiation.

Keratinocyte G2/M growth arrest by 1,25-dihydroxyvitamin D3 is caused by Cdc2 phosphorylation through Wee1 and Myt1 regulation.

Enzymes involved in the activation and inactivation of vitamin D.

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2271-2280

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10.1038/JID.2008.62

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9

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128

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Andrzej Slominski

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Robert C Tuckey

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2008-03-27T00:00:00Z

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18368131

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