Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities.
about
BRCA1 affects global DNA methylation through regulation of DNMT1BRCA1 is an essential regulator of heart function and survival following myocardial infarctionATM activation by ionizing radiation requires BRCA1-associated BAAT1Roles of BRCA1 in centrosome duplicationBRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation siteBRCA1 and BRCA2 proteins: roles in health and diseaseBASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structuresDirect DNA binding by Brca1Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor l(2)tid, is critical for early embryonic development and cell survivalThe BRCA2 gene product functionally interacts with p53 and RAD51Increased cell survival by inhibition of BRCA1 using an antisense approach in an estrogen responsive ovarian carcinoma cell lineCaretaker Brca1: keeping the genome in the straight and narrow.Role of BRCA gene dysfunction in breast and ovarian cancer predisposition.A guide for functional analysis of BRCA1 variants of uncertain significanceDouble-strand break repair on sex chromosomes: challenges during male meiotic prophaseThe Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changesAnalysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signalsBRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transitionEssential role for sphingosine kinases in neural and vascular developmentGenetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closureVIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signalingTumor suppressor gene BRCA-1 is expressed by embryonic and adult neural stem cells and involved in cell proliferationOvca1 regulates cell proliferation, embryonic development, and tumorigenesisPalb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancerTumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutationBARD1 participates with BRCA1 in homology-directed repair of chromosome breaksAnalysis of missense variation in human BRCA1 in the context of interspecific sequence variationChromatin remodeling and activation of chromosomal DNA replication by an acidic transcriptional activation domain from BRCA1.Clinical and molecular characterization of the BRCA2 p.Asn3124Ile variant reveals substantial evidence for pathogenic significance.A homologue of the breast cancer-associated gene BARD1 is involved in DNA repair in plantsA novel genetic mechanism regulates dorsolateral hinge-point formation during zebrafish cranial neurulation.Role of BRCA1 in brain development.The Mouse Tumor Biology Database: integrated access to mouse cancer biology data.Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells.Heterozygosity for a mutation in Brca1 or Atm does not increase susceptibility to ENU-induced mammary tumors in Apc(Min)/+ mice.Mapping and conformational characterization of the DNA-binding region of the breast cancer susceptibility protein BRCA1.Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers.Rapid detection of carriers with BRCA1 and BRCA2 mutations using high resolution melting analysis.The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins.Transcription-coupled repair of DNA damage: unanticipated players, unexpected complexities.
P2860
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P2860
Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities.
description
1996 nî lūn-bûn
@nan
1996 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Brca1 deficiency results in ea ...... neuroepithelial abnormalities.
@ast
Brca1 deficiency results in ea ...... neuroepithelial abnormalities.
@en
Brca1 deficiency results in ea ...... neuroepithelial abnormalities.
@nl
type
label
Brca1 deficiency results in ea ...... neuroepithelial abnormalities.
@ast
Brca1 deficiency results in ea ...... neuroepithelial abnormalities.
@en
Brca1 deficiency results in ea ...... neuroepithelial abnormalities.
@nl
prefLabel
Brca1 deficiency results in ea ...... neuroepithelial abnormalities.
@ast
Brca1 deficiency results in ea ...... neuroepithelial abnormalities.
@en
Brca1 deficiency results in ea ...... neuroepithelial abnormalities.
@nl
P2093
P2860
P356
P1433
P1476
Brca1 deficiency results in ea ...... neuroepithelial abnormalities.
@en
P2093
P2860
P2888
P304
P356
10.1038/NG0296-191
P407
P577
1996-02-01T00:00:00Z