A novel suicide substrate for DNA topoisomerases and site-specific recombinases
about
The role of lysine 532 in the catalytic mechanism of human topoisomerase INonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analogStructural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complexA novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerasesViewing single lambda site-specific recombination events from start to finishRapid microtiter assays for poxvirus topoisomerase, mammalian type IB topoisomerase and HIV-1 integrase: application to inhibitor isolationVaccinia topoisomerase and Cre recombinase catalyze direct ligation of activated DNA substrates containing a 3'-para-nitrophenyl phosphate ester.SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivityEvaluation of two models for human topoisomerase I interaction with dsDNA and camptothecin derivativesSin resolvase catalytic activity and oligomerization state are tightly coupled.Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.A general and efficient approach for the construction of RNA oligonucleotides containing a 5'-phosphorothiolate linkage.Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV.Repair of topoisomerase I-mediated DNA damage.Mutation of Gly721 alters DNA topoisomerase I active site architecture and sensitivity to camptothecin.Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases.Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalphaMixing active-site components: a recipe for the unique enzymatic activity of a telomere resolvase.Oligonucleotide-directed gene-editing technology: mechanisms and future prospects.Gamma integrase complementation at the level of DNA binding and complex formation.New chemically reactive dsDNAs containing single internucleotide monophosphoryldithio links: reactivity of 5'-mercapto-oligodeoxyribonucleotides.A functional linker in human topoisomerase I is required for maximum sensitivity to camptothecin in a DNA relaxation assay.DNA gyrase can cleave short DNA fragments in the presence of quinolone drugs.Mechanisms of DNA damage, repair, and mutagenesis.Recombinogenic flap ligation pathway for intrinsic repair of topoisomerase IB-induced double-strand breaks.Regulation of site-specific recombination by the C-terminus of lambda integrase.Characterization of mimivirus DNA topoisomerase IB suggests horizontal gene transfer between eukaryal viruses and bacteria.Nicked-site substrates for a serine recombinase reveal enzyme-DNA communications and an essential tethering role of covalent enzyme-DNA linkages.Spring loading a pre-cleavage intermediate for hairpin telomere formationDNA contacts stimulate catalysis by a poxvirus topoisomerase.Asymmetry in Flp-mediated cleavage.Vaccinia topoisomerase mutants illuminate conformational changes during closure of the protein clamp and assembly of a functional active site.Pathways for repair of topoisomerase I covalent complexes in Saccharomyces cerevisiae.19F NMR studies of vaccinia type IB topoisomerase. Conformational dynamics of the bound DNA substrate.Proton relay mechanism of general acid catalysis by DNA topoisomerase IB.Substitution of conserved residues within the active site alters the cleavage religation equilibrium of DNA topoisomerase I.Uncoupling the chemical steps of telomere resolution by ResT.Metal ion catalysis during splicing of premessenger RNA
P2860
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P2860
A novel suicide substrate for DNA topoisomerases and site-specific recombinases
description
1995 nî lūn-bûn
@nan
1995 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
A novel suicide substrate for DNA topoisomerases and site-specific recombinases
@ast
A novel suicide substrate for DNA topoisomerases and site-specific recombinases
@en
A novel suicide substrate for DNA topoisomerases and site-specific recombinases
@nl
type
label
A novel suicide substrate for DNA topoisomerases and site-specific recombinases
@ast
A novel suicide substrate for DNA topoisomerases and site-specific recombinases
@en
A novel suicide substrate for DNA topoisomerases and site-specific recombinases
@nl
prefLabel
A novel suicide substrate for DNA topoisomerases and site-specific recombinases
@ast
A novel suicide substrate for DNA topoisomerases and site-specific recombinases
@en
A novel suicide substrate for DNA topoisomerases and site-specific recombinases
@nl
P2093
P2860
P921
P356
P1476
A novel suicide substrate for DNA topoisomerases and site-specific recombinases
@en
P2093
Burgin AB Jr
Huizenga BN
P2860
P304
P356
10.1093/NAR/23.15.2973
P407
P577
1995-08-01T00:00:00Z