Pharmacological characterization of the allosteric modulator desformylflustrabromine and its interaction with alpha4beta2 neuronal nicotinic acetylcholine receptor orthosteric ligands.
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Allosteric modulator Desformylflustrabromine relieves the inhibition of α2β2 and α4β2 nicotinic acetylcholine receptors by β-amyloid(1-42) peptideUnravelling the mechanism of action of NS9283, a positive allosteric modulator of (α4)3(β2)2 nicotinic ACh receptorsDeconstruction of the α4β2 nicotinic acetylcholine receptor positive allosteric modulator desformylflustrabromineNMR structures of the transmembrane domains of the α4β2 nAChRTargeting α4β2 nicotinic acetylcholine receptors in central nervous system disorders: perspectives on positive allosteric modulation as a therapeutic approach.Attenuation of Compulsive-Like Behavior Through Positive Allosteric Modulation of α4β2 Nicotinic Acetylcholine Receptors in Non-Induced Compulsive-Like MiceAugmentation of cognitive function by NS9283, a stoichiometry-dependent positive allosteric modulator of α2- and α4-containing nicotinic acetylcholine receptors.Platelet activating factor blocks interkinetic nuclear migration in retinal progenitors through an arrest of the cell cycle at the S/G2 transition.Allosteric modulators of the α4β2 subtype of neuronal nicotinic acetylcholine receptors.Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations.Structure-activity relationship studies of sulfonylpiperazine analogues as novel negative allosteric modulators of human neuronal nicotinic receptors.Desformylflustrabromine Modulates α4β2 Neuronal Nicotinic Acetylcholine Receptor High- and Low-Sensitivity Isoforms at Allosteric Clefts Containing the β2 SubunitDefining the putative inhibitory site for a selective negative allosteric modulator of human α4β2 neuronal nicotinic receptorsA Novel α2/α4 Subtype-selective Positive Allosteric Modulator of Nicotinic Acetylcholine Receptors Acting from the C-tail of an α SubunitAllosteric modulation of alpha4beta2 nicotinic acetylcholine receptors by HEPESPositive allosteric modulation of α4β2 nicotinic acetylcholine receptors as a new approach to smoking reduction: evidence from a rat model of nicotine self-administration.Recent progress in neuroactive marine natural products.Allosteric modulators of α4β2 nicotinic acetylcholine receptors: a new direction for antidepressant drug discovery.Allosteric modulation of α4β2* nicotinic acetylcholine receptors: Desformylflustrabromine potentiates antiallodynic response of nicotine in a mouse model of neuropathic pain.Orthosteric and allosteric potentiation of heteromeric neuronal nicotinic acetylcholine receptors.Effects of soluble β-amyloid on the release of neurotransmitters from rat brain synaptosomes.Selective potentiation of (α4)3(β2)2 nicotinic acetylcholine receptors augments amplitudes of prefrontal acetylcholine- and nicotine-evoked glutamatergic transients in ratsRabies virus modifies host behaviour through a snake-toxin like region of its glycoprotein that inhibits neurotransmitter receptors in the CNS.Effects of nicotine in combination with drugs described as positive allosteric nicotinic acetylcholine receptor modulators in vitro: discriminative stimulus and hypothermic effects in mice.LY2087101 and dFBr share transmembrane binding sites in the (α4)3(β2)2 Nicotinic Acetylcholine Receptor.Role of the Cys Loop and Transmembrane Domain in the Allosteric Modulation of α4β2 Nicotinic Acetylcholine Receptors.
P2860
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P2860
Pharmacological characterization of the allosteric modulator desformylflustrabromine and its interaction with alpha4beta2 neuronal nicotinic acetylcholine receptor orthosteric ligands.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Pharmacological characterizati ...... receptor orthosteric ligands.
@ast
Pharmacological characterizati ...... receptor orthosteric ligands.
@en
Pharmacological characterizati ...... receptor orthosteric ligands.
@nl
type
label
Pharmacological characterizati ...... receptor orthosteric ligands.
@ast
Pharmacological characterizati ...... receptor orthosteric ligands.
@en
Pharmacological characterizati ...... receptor orthosteric ligands.
@nl
prefLabel
Pharmacological characterizati ...... receptor orthosteric ligands.
@ast
Pharmacological characterizati ...... receptor orthosteric ligands.
@en
Pharmacological characterizati ...... receptor orthosteric ligands.
@nl
P2860
P356
P1476
Pharmacological characterizati ...... receptor orthosteric ligands.
@en
P2093
Maegan M Weltzin
Marvin K Schulte
P2860
P304
P356
10.1124/JPET.110.167684
P407
P577
2010-06-01T00:00:00Z