Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics
about
The ubiquitin proteasomal system: a potential target for the management of Alzheimer's diseaseDegrons of yeast and mammalian ornithine decarboxylase enzymes make potent combination for regulated targeted protein degradation.Targeting the undruggable proteome: the small molecules of my dreams.Nucleating the assembly of macromolecular complexes.Protacs for treatment of cancer.The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solutionUbiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implicationsDesign and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One.A HaloTag-based small molecule microarray screening methodology with increased sensitivity and multiplex capabilities.HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.Catalytic in vivo protein knockdown by small-molecule PROTACs.Induced protein degradation: an emerging drug discovery paradigm.Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic TaggingChemical approaches to targeted protein degradation through modulation of the ubiquitin-proteasome pathwaySmall molecule therapeutics targeting F-box proteins in cancer.Chemical inducers of targeted protein degradation.The ends and means of artificially induced targeted protein degradation.Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome systemSCF ubiquitin ligase-targeted therapies.Targeted Protein Degradation by Small Molecules.Waste disposal-An attractive strategy for cancer therapy.Targeted protein knockdown using small molecule degraders.Targeted Protein Degradation: from Chemical Biology to Drug Discovery.Impact of linker length on the activity of PROTACs.Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands.Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation.Clinical and molecular insights into adenoid cystic carcinoma: Neural crest‐like stemness as a target.The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study.Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders.Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist.Clinical and molecular insights into adenoid cystic carcinoma: Neural crest-like stemness as a target.Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC).Small Molecule Modulators of RING-Type E3 Ligases: MDM and Cullin Families as Targets.Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugsPharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinaseNext-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation
P2860
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P2860
Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics
description
2008 nî lūn-bûn
@nan
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Targeted intracellular protein ...... n route to chemical proteomics
@ast
Targeted intracellular protein ...... n route to chemical proteomics
@en
Targeted intracellular protein ...... n route to chemical proteomics
@nl
type
label
Targeted intracellular protein ...... n route to chemical proteomics
@ast
Targeted intracellular protein ...... n route to chemical proteomics
@en
Targeted intracellular protein ...... n route to chemical proteomics
@nl
prefLabel
Targeted intracellular protein ...... n route to chemical proteomics
@ast
Targeted intracellular protein ...... n route to chemical proteomics
@en
Targeted intracellular protein ...... n route to chemical proteomics
@nl
P2093
P2860
P1476
Targeted intracellular protein ...... n route to chemical proteomics
@en
P2093
Ashley R Schneekloth
Craig M Crews
Hyun Seop Tae
P2860
P304
P356
10.1016/J.BMCL.2008.07.114
P407
P577
2008-07-31T00:00:00Z