Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models.
about
Aspartame: A Safety Evaluation Based on Current Use Levels, Regulations, and Toxicological and Epidemiological StudiesThe role of transgenic mouse models in carcinogen identificationPrediction of rodent nongenotoxic carcinogenesis: evaluation of biochemical and tissue changes in rodents following exposure to nine nongenotoxic NTP carcinogens.The p53 heterozygous knockout mouse as a model for chemical carcinogenesis in vascular tissueWhen NRF2 talks, who's listening?Drinking water disinfection byproducts: review and approach to toxicity evaluationUse of transgenic animals for carcinogenicity testing: considerations and implications for risk assessment.Analysis for loss of heterozygosity (LOH) of p53 allele in tumors derived from p53+/- and CD-1 mice following repeated subcutaneous injections of solutions containing antioxidants.Use of DNA repair-deficient XPA transgenic mice in short-term carcinogenicity testing.Utilization of genetically altered animals in the pharmaceutical industry.Evaluation of the Xpa-deficient transgenic mouse model for short-term carcinogenicity testing: 9-month studies with haloperidol, reserpine, phenacetin, and D-mannitol.Mechanism-based cancer prevention approaches: targets, examples, and the use of transgenic mice.Stem cell proliferation patterns as an alternative for in vivo prediction and discrimination of carcinogenic compounds.Survival rates of homozygotic Tp53 knockout rats as a tool for preclinical assessment of cancer prevention and treatmentAssessing the potential carcinogenic activity of magnetic fields using animal models.Assessment of immunosuppressant drug carcinogenicity: standard and alternative animal models.Cancer prevention studies in p53-deficient mice.Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.Evaluation of the carcinogenic potential of clofibrate in the neonatal mouse.Measurement of micronucleated erythrocytes and DNA damage during chronic ingestion of phenolphthalein in transgenic female mice heterozygous for the p53 gene.Use of genetically engineered mice in drug discovery and development: wielding Occam's razor to prune the product portfolio.Evaluation of the Tg.AC transgenic mouse assay for testing the human carcinogenic potential of pharmaceuticals--practical pointers, mechanistic clues, and new questions.Predictions for the outcome of rodent carcinogenicity bioassays: identification of trans-species carcinogens and noncarcinogens.Topics in cancer risk assessment.Update on national toxicology program (NTP) assays with genetically altered or "transgenic" mice.In vivo transgenic bioassays and assessment of the carcinogenic potential of pharmaceuticalsValidation of transgenic mice carrying the human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testingThe U.S. National Toxicology Program evaluation of transgenic mice as predictive models for identifying carcinogens.Evaluation and validation issues in the development of transgenic mouse carcinogenicity bioassays.Current approaches toward chemical mixture studies at the National Institute of Environmental Health Sciences and the U.S. National Toxicology Program.The use of genetically modified mice in cancer risk assessment: challenges and limitations.Power, expertise and the limits of representative democracy: genetics as scientific progress or political legitimation in carcinogenic risk assessment of pharmaceuticals?Biological, cellular, and molecular characteristics of an inducible transgenic skin tumor model: a review.Toxicology and carcinogenesis study of senna in C3B6.129F1-Trp53 tm1Brd N12 haploinsufficient mice.Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice.An industry perspective on the utility of short-term carcinogenicity testing in transgenic mice in pharmaceutical development.Current Status of Short-Term Tests for Evaluation of Genotoxicity, Mutagenicity, and Carcinogenicity of Environmental Chemicals and NCEs.Safety assessment of triethanolamine and triethanolamine-containing ingredients as used in cosmetics.Twenty-six-week oral carcinogenicity study of 3-monochloropropane-1,2-diol in CB6F1-rasH2 transgenic mice.Review of Research Trends and Methods in Nano Environmental, Health, and Safety Risk Analysis.
P2860
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P2860
Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models.
description
1995 nî lūn-bûn
@nan
1995 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Identifying chemical carcinoge ...... using transgenic mouse models.
@ast
Identifying chemical carcinoge ...... using transgenic mouse models.
@en
Identifying chemical carcinoge ...... using transgenic mouse models.
@nl
type
label
Identifying chemical carcinoge ...... using transgenic mouse models.
@ast
Identifying chemical carcinoge ...... using transgenic mouse models.
@en
Identifying chemical carcinoge ...... using transgenic mouse models.
@nl
prefLabel
Identifying chemical carcinoge ...... using transgenic mouse models.
@ast
Identifying chemical carcinoge ...... using transgenic mouse models.
@en
Identifying chemical carcinoge ...... using transgenic mouse models.
@nl
P2093
P2860
P356
P1476
Identifying chemical carcinoge ...... using transgenic mouse models.
@en
P2093
J E French
J W Spalding
R W Tennant
P2860
P304
P356
10.1289/EHP.95103942
P577
1995-10-01T00:00:00Z