Murine coronavirus-induced hepatitis: JHM genetic background eliminates A59 spike-determined hepatotropism
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Mechanisms of coronavirus cell entry mediated by the viral spike proteinMurine Coronavirus Mouse Hepatitis Virus Is Recognized by MDA5 and Induces Type I Interferon in Brain Macrophages/MicrogliaRecombinant mouse hepatitis virus strain A59 from cloned, full-length cDNA replicates to high titers in vitro and is fully pathogenic in vivoMurine coronavirus evolution in vivo: functional compensation of a detrimental amino acid substitution in the receptor binding domain of the spike glycoprotein.Contributions of the viral genetic background and a single amino acid substitution in an immunodominant CD8+ T-cell epitope to murine coronavirus neurovirulence.Pathogenesis of murine coronavirus in the central nervous system.Structural genomics of the severe acute respiratory syndrome coronavirus: nuclear magnetic resonance structure of the protein nsP7Genetic determinants of mouse hepatitis virus strain 1 pneumovirulence.Murine coronavirus receptors are differentially expressed in the central nervous system and play virus strain-dependent roles in neuronal spreadCoronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus.Both spike and background genes contribute to murine coronavirus neurovirulenceMurine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice.Cell-type-specific type I interferon antagonism influences organ tropism of murine coronavirusThe nsp1, nsp13, and M proteins contribute to the hepatotropism of murine coronavirus JHM.WU.A hypervariable region within the 3' cis-acting element of the murine coronavirus genome is nonessential for RNA synthesis but affects pathogenesisDifferential induction of proinflammatory cytokines in primary mouse astrocytes and microglia by coronavirus infectionInhibition of the alpha/beta interferon response by mouse hepatitis virus at multiple levels.Suppression subtractive hybridization method for the identification of a new strain of murine hepatitis virus from xenografted SCID mice.The spike glycoprotein of murine coronavirus MHV-JHM mediates receptor-independent infection and spread in the central nervous systems of Ceacam1a-/- MiceChimeric coronavirus-like particles carrying severe acute respiratory syndrome coronavirus (SCoV) S protein protect mice against challenge with SCoVPriming of CD8+ T cells during central nervous system infection with a murine coronavirus is strain dependent.Cell-type-specific activation of the oligoadenylate synthetase-RNase L pathway by a murine coronavirus.Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity.Organ-specific attenuation of murine hepatitis virus strain A59 by replacement of catalytic residues in the putative viral cyclic phosphodiesterase ns2.Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins.Murine coronavirus neuropathogenesis: determinants of virulence.MDA5 Is Critical to Host Defense during Infection with Murine Coronavirus.Replicase genes of murine coronavirus strains A59 and JHM are interchangeable: differences in pathogenesis map to the 3' one-third of the genome.Expression of hemagglutinin esterase protein from recombinant mouse hepatitis virus enhances neurovirulence.Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice.The murine coronavirus nucleocapsid gene is a determinant of virulence.Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology.
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P2860
Murine coronavirus-induced hepatitis: JHM genetic background eliminates A59 spike-determined hepatotropism
description
2003 nî lūn-bûn
@nan
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Murine coronavirus-induced hep ...... spike-determined hepatotropism
@ast
Murine coronavirus-induced hep ...... spike-determined hepatotropism
@en
Murine coronavirus-induced hep ...... spike-determined hepatotropism
@nl
type
label
Murine coronavirus-induced hep ...... spike-determined hepatotropism
@ast
Murine coronavirus-induced hep ...... spike-determined hepatotropism
@en
Murine coronavirus-induced hep ...... spike-determined hepatotropism
@nl
prefLabel
Murine coronavirus-induced hep ...... spike-determined hepatotropism
@ast
Murine coronavirus-induced hep ...... spike-determined hepatotropism
@en
Murine coronavirus-induced hep ...... spike-determined hepatotropism
@nl
P2860
P1433
P1476
Murine coronavirus-induced hep ...... spike-determined hepatotropism
@en
P2093
Sonia Navas
P2860
P304
P356
10.1128/JVI.77.8.4972-4978.2003
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2003-04-01T00:00:00Z