Small molecule blockers of the Alzheimer Abeta calcium channel potently protect neurons from Abeta cytotoxicity. - Wikidata - awgldk - TriplyDB

Small molecule blockers of the Alzheimer Abeta calcium channel potently protect neurons from Abeta cytotoxicity.

Small molecule blockers of the Alzheimer Abeta calcium channel potently protect neurons from Abeta cytotoxicity.

http://www.wikidata.org/entity/Q34940747

about

The toxicity of amyloid β oligomers Signaling effect of amyloid-beta(42) on the processing of AbetaPP Calcium channel blockers and Alzheimer's disease Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives Models of membrane-bound Alzheimer's Abeta peptide assemblies Single molecule characterization of the interactions between amyloid-β peptides and the membranes of hippocampal cells.Calcium signaling and amyloid toxicity in Alzheimer disease.Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease.Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases Alzheimer's disease: which type of amyloid-preventing drug agents to employ?Multivariate analyses of amyloid-beta oligomer populations indicate a connection between pore formation and cytotoxicity β-amyloid oligomers and prion protein: Fatal attraction?From a Cell's Viewpoint: Targeting Mitochondria in Alzheimer's disease Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein.Single-molecule imaging reveals that small amyloid-β1-42 oligomers interact with the cellular prion protein (PrP(C))Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions.Calcium channel blocking as a therapeutic strategy for Alzheimer's disease: the case for isradipine.Analyzing and Modeling the Kinetics of Amyloid Beta Pores Associated with Alzheimer's Disease Pathology.Antimicrobial properties of amyloid peptides.Two-step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formation Identification of 4-aminoquinoline core for the design of new cholinesterase inhibitors Embedding Aβ42 in heterogeneous membranes depends on cholesterol asymmetries Misfolded amyloid ion channels present mobile beta-sheet subunits in contrast to conventional ion channels Rare individual amyloid-β oligomers act on astrocytes to initiate neuronal damage.Oxidative stress and cell membranes in the pathogenesis of Alzheimer's disease.New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc.Disruption of zinc homeostasis and the pathogenesis of senile dementia.Molecular understanding of a potential functional link between antimicrobial and amyloid peptides.Dantrolene, a treatment for Alzheimer disease?Endogenously generated amyloid-β increases stiffness in human neuroblastoma cells.Amyloid beta: structure, biology and structure-based therapeutic development.Sublethal doses of β-amyloid peptide abrogate DNA-dependent protein kinase activity.Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases.Membrane-Accelerated Amyloid-β Aggregation and Formation of Cross-β Sheets.Biometal Dyshomeostasis and Toxic Metal Accumulations in the Development of Alzheimer's Disease.The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.Hematite-Based Photoelectrode Materials for Photoelectrocatalytic Inhibition of Alzheimer's β-Amyloid Self-Assembly.Soluble Oligomers Require a Ganglioside to Trigger Neuronal Calcium Overload.Imidazole improves cognition and balances Alzheimer's-like intracellular calcium homeostasis in transgenic Drosophila model.

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P2860

Small molecule blockers of the Alzheimer Abeta calcium channel potently protect neurons from Abeta cytotoxicity.

http://www.wikidata.org/entity/Q34940747

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2009 nî lūn-bûn

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2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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Small molecule blockers of the ...... urons from Abeta cytotoxicity.

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Harvey B Pollard

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Juan Carlos Diaz

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Kenneth A Jacobson

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Nelson Arispe

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P2860

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease

Pathways towards and away from Alzheimer's disease

Molecular basis for passive immunotherapy of Alzheimer's disease

Alzheimer's disease: genes, proteins, and therapy

Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum

Reversible memory loss in a mouse transgenic model of Alzheimer's disease

Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein

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19204293

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Alzheimer's disease

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2637905

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