Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation - Wikidata - awgldk - TriplyDB

Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation

Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation

http://www.wikidata.org/entity/Q34946238

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Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1 Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo CDK2 regulation through PI3K and CDK4 is necessary for cell cycle progression of primary rat hepatocytes RB-dependent S-phase response to DNA damage Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice Combining mTOR inhibition with radiation improves antitumor activity in bladder cancer cells in vitro and in vivo: a novel strategy for treatment.Extracting gene expression patterns and identifying co-expressed genes from microarray data reveals biologically responsive processes.A novel cinnamic acid derivative that inhibits Cdc25 dual-specificity phosphatase activity.Loss of p21Waf1/Cip1/Sdi1 enhances intestinal stem cell survival following radiation injury Sulforaphane Increases Cyclin-Dependent Kinase Inhibitor, p21 Protein in Human Oral Carcinoma Cells and Nude Mouse Animal Model to Induce G(2)/M Cell Cycle Arrest Up-regulation of p21 and TNF-alpha is mediated in lycorine-induced death of HL-60 cells.Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks.p21WAF1/CIP1 gene transcriptional activation exerts cell growth inhibition and enhances chemosensitivity to cisplatin in lung carcinoma cell.MicroRNA-17~92 is required for nephrogenesis and renal function Cyclin D activates the Rb tumor suppressor by mono-phosphorylation A context-specific role for retinoblastoma protein-dependent negative growth control in suppressing mammary tumorigenesis.Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells.Establishment of irreversible growth arrest in myogenic differentiation requires the RB LXCXE-binding function.Dna damage-induced G(1) arrest in hematopoietic cells is overridden following phosphatidylinositol 3-kinase-dependent activation of cyclin-dependent kinase 2 Cyr61, a member of CCN family, is a tumor suppressor in non-small cell lung cancer.Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice.Mechanisms of cell-cycle checkpoints: at the crossroads of carcinogenesis and drug discovery.The cyclin-dependent kinase inhibitor SCH 727965 (dinacliclib) induces the apoptosis of osteosarcoma cells Mechanism-based screen establishes signalling framework for DNA damage-associated G1 checkpoint response.DNA damage signals through differentially modified E2F1 molecules to induce apoptosis.The silencing of Pokemon attenuates the proliferation of hepatocellular carcinoma cells in vitro and in vivo by inhibiting the PI3K/Akt pathway P21Waf1 control of epithelial cell cycle and cell fate.Analysing p53 tumour suppressor functions in mice.p53 downstream targets and chemosensitivity.The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest.Radiosensitization by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under oxia and hypoxia in human colon cancer cells.Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse.A systems biology dynamical model of mammalian G1 cell cycle progression.Effect of methotrexate on cerebellar development in infant rats p53 mediates senescence-like arrest induced by chronic replicational stress Lack of a p21waf1/cip -dependent G1/S checkpoint in neural stem and progenitor cells after DNA damage in vivo.MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint.

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P2860

Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation

http://www.wikidata.org/entity/Q34946238

description

1999 nî lūn-bûn

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1999 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի փետրվարին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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Inhibition of cyclin-dependent ...... arrest after gamma-irradiation

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Inhibition of cyclin-dependent ...... arrest after gamma-irradiation

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Inhibition of cyclin-dependent ...... arrest after gamma-irradiation

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Inhibition of cyclin-dependent ...... arrest after gamma-irradiation

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Inhibition of cyclin-dependent ...... arrest after gamma-irradiation

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Inhibition of cyclin-dependent ...... arrest after gamma-irradiation

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Proceedings of the National Academy of Sciences of the United States of America

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Inhibition of cyclin-dependent ...... arrest after gamma-irradiation

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J A Lees

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J Brugarolas

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K Moberg

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S D Boyd

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P2860

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2

The retinoblastoma protein is phosphorylated on multiple sites by human cdc2

Human cyclin E, a nuclear protein essential for the G1-to-S phase transition

Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb

WAF1, a potential mediator of p53 tumor suppression

p21 is a universal inhibitor of cyclin kinases

Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage

p21 is necessary for the p53-mediated G1 arrest in human cancer cells

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1002-1007

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