Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus. - Wikidata - awgldk - TriplyDB

Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus.

Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus.

http://www.wikidata.org/entity/Q34962651

about

Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's Disease Insights into Neuroinflammation in Parkinson's Disease: From Biomarkers to Anti-Inflammatory Based Therapies Evidence of inflammatory system involvement in Parkinson's disease.Splicing: is there an alternative contribution to Parkinson's disease?LRRK2 and ubiquitination: implications for kinase inhibitor therapy LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn's disease patients.Genetic, structural, and molecular insights into the function of ras of complex proteins domains.Cellular processes associated with LRRK2 function and dysfunction Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.Advances in understanding genomic markers and pharmacogenetics of Parkinson's disease.The use of deceased controls in epidemiological research: A systematic review.Increased brain expression of GPNMB is associated with genome wide significant risk for Parkinson's disease on chromosome 7p15.3.Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells.The LRRK2 signalling system.LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils.Linking a genome-wide association study signal to a LRRK2 coding variant in Parkinson's disease.NOD2 and CCDC122-LACC1 genes are associated with leprosy susceptibility in Brazilians.Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease.Leucine Rich Repeat Kinase 2: beyond Parkinson's and beyond kinase inhibitors.Insights into the Influence of Specific Splicing Events on the Structural Organization of

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Fine-mapping, gene expression and splicing analysis of the disease associated LRRK2 locus.

http://www.wikidata.org/entity/Q34962651

description

2013 nî lūn-bûn

@nan

2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2013年の論文

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2013年論文

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2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Fine-mapping, gene expression ...... isease associated LRRK2 locus.

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Fine-mapping, gene expression ...... isease associated LRRK2 locus.

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Fine-mapping, gene expression ...... isease associated LRRK2 locus.

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type

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Fine-mapping, gene expression ...... isease associated LRRK2 locus.

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Fine-mapping, gene expression ...... isease associated LRRK2 locus.

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Fine-mapping, gene expression ...... isease associated LRRK2 locus.

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Fine-mapping, gene expression ...... isease associated LRRK2 locus.

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Fine-mapping, gene expression ...... isease associated LRRK2 locus.

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Fine-mapping, gene expression ...... isease associated LRRK2 locus.

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Fine-mapping, gene expression ...... isease associated LRRK2 locus.

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Adamantios Mamais

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Colin Smith

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Dena Hernandez

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Eric Schadt

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International Parkinson Disease Genomics Consortium (IPDGC)

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Jana Vandrovcova

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Javier Simon-Sanchez

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Karl J Lackner

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Manu Sharma

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Michael A Nalls

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P2860

A two-stage meta-analysis identifies several new loci for Parkinson's disease

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative study

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes

PLINK: a tool set for whole-genome association and population-based linkage analyses

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e70724

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Vincent Plagnol

Jana Vandrovcova

Patrick A. Lewis

Michael E. Weale

Nicholas W. Wood

Andrew Singleton

Daniah Trabzuni

Adaikalavan Ramasamy

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2013-08-13T00:00:00Z

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