A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4
about
SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53Enhancer malfunction in cancerRecent progress toward epigenetic therapies: the example of mixed lineage leukemiaHistone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and preventionHijacked in cancer: the KMT2 (MLL) family of methyltransferasesThe plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferasesThe genetic landscape of the childhood cancer medulloblastomaEstablishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model systemDisordered epigenetic regulation in MLL-related leukemia.The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.Involvement of Chromatin Remodeling Genes and the Rho GTPases RhoB and CDC42 in Ovarian Clear Cell Carcinoma.Clinico-pathological description of three paediatric medulloblastoma cases with MLL2/3 gene mutations.Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancerKMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation.Viral carcinogenesis: factors inducing DNA damage and virus integrationAsh2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters.Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer.Tumor suppressor p53 regulates bile acid homeostasis via small heterodimer partner.Genomic analyses of gynaecologic carcinosarcomas reveal frequent mutations in chromatin remodelling genesGenetic alterations of histone lysine methyltransferases and their significance in breast cancerAn Lnc RNA (GAS5)/SnoRNA-derived piRNA induces activation of TRAIL gene by site-specifically recruiting MLL/COMPASS-like complexes.Requirement for MLL3 in p53 regulation of hepatic expression of small heterodimer partner and bile acid homeostasis.The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients.Histone recognition and nuclear receptor co-activator functions of Drosophila cara mitad, a homolog of the N-terminal portion of mammalian MLL2 and MLL3Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liverLoss of Mll3 Catalytic Function Promotes Aberrant MyelopoiesisX-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific mannerAlcohol-dysregulated miR-30a and miR-934 in head and neck squamous cell carcinomaAlteration of histone H3K4 methylation in glomerular podocytes associated with proteinuria in patients with membranous nephropathy.The miR-200 family is increased in dysplastic lesions in ulcerative colitis patients.Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathwaysMutation of epigenetic regulators TET2 and MLL3 in patients with HTLV-I-induced acute adult T-cell leukemia.Interaction between MLL3 genetic polymorphisms, smoking, and alcohol drinking in laryngeal cancer: a case-control studyAcetylation dynamics of human nuclear proteins during the ionizing radiation-induced DNA damage responseWhole-genome sequencing identifies recurrent mutations in hepatocellular carcinomaMolecular signature of pancreatic adenocarcinoma: an insight from genotype to phenotype and challenges for targeted therapy.Identification of driver genes in hepatocellular carcinoma by exome sequencing.Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies.Histone H3K27 trimethylation inhibits H3 binding and function of SET1-like H3K4 methyltransferase complexes.
P2860
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P2860
A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
A tumor suppressive coactivato ...... ase MLL3 or its paralogue MLL4
@ast
A tumor suppressive coactivato ...... ase MLL3 or its paralogue MLL4
@en
A tumor suppressive coactivato ...... ase MLL3 or its paralogue MLL4
@nl
type
label
A tumor suppressive coactivato ...... ase MLL3 or its paralogue MLL4
@ast
A tumor suppressive coactivato ...... ase MLL3 or its paralogue MLL4
@en
A tumor suppressive coactivato ...... ase MLL3 or its paralogue MLL4
@nl
prefLabel
A tumor suppressive coactivato ...... ase MLL3 or its paralogue MLL4
@ast
A tumor suppressive coactivato ...... ase MLL3 or its paralogue MLL4
@en
A tumor suppressive coactivato ...... ase MLL3 or its paralogue MLL4
@nl
P2093
P2860
P356
P1476
A tumor suppressive coactivato ...... ase MLL3 or its paralogue MLL4
@en
P2093
Dae-Hwan Kim
Dong Kee Lee
Jeongkyung Lee
Qi-Heng Yang
Robert G Roeder
Seunghee Lee
Soo-Kyung Lee
P2860
P304
P356
10.1073/PNAS.0902873106
P407
P577
2009-05-11T00:00:00Z