Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice - Wikidata - awgldk - TriplyDB

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

http://www.wikidata.org/entity/Q34997279

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PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicine Multiple facets of TPP1 in telomere maintenance Molecular regulation of telomerase activity in aging Replication stress in Mammalian cells and its consequences for mitosis Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1 BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping TRF2 interaction with Ku heterotetramerization interface gives insight into c-NHEJ prevention at human telomeres ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity The role of telomeres and telomerase in stem cell aging ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion A balance between elongation and trimming regulates telomere stability in stem cells RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.TopoIIα prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeres TRF1 ensures the centromeric function of Aurora-B and proper chromosome segregation.The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase.SIRT1 is necessary for proficient telomere elongation and genomic stability of induced pluripotent stem cells.Telomeres: protecting chromosomes against genome instability Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma Impact papers on aging in 2009.ATR contributes to telomere maintenance in human cells Rho GDP-dissociation inhibitor α is a potential prognostic biomarker and controls telomere regulation in colorectal cancer Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis.Repair of endogenous DNA base lesions modulate lifespan in mice The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeres Suv4-20h abrogation enhances telomere elongation during reprogramming and confers a higher tumorigenic potential to iPS cells G-quadruplex nucleic acids and human disease The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development.The role of telomeres and telomerase in cancer research.Removal of shelterin reveals the telomere end-protection problem.Human CST promotes telomere duplex replication and general replication restart after fork stalling.

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Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

http://www.wikidata.org/entity/Q34997279

description

2009 nî lūn-bûn

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2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի օգոստոսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Increased telomere fragility a ...... s and increased cancer in mice

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Increased telomere fragility a ...... s and increased cancer in mice

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Increased telomere fragility a ...... s and increased cancer in mice

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Increased telomere fragility a ...... s and increased cancer in mice

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Increased telomere fragility a ...... s and increased cancer in mice

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Increased telomere fragility a ...... s and increased cancer in mice

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Carolyn McNees

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Chunyan Liao

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Juana M Flores

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Madalena Tarsounas

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Maria Thanasoula

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Paula Martínez

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Purificación Muñoz

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P2860

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

A telomerase component is defective in the human disease dyskeratosis congenita

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres

Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2

Protein requirements for sister telomere association in human cells

ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

POT1 as a terminal transducer of TRF1 telomere length control

Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

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2060-2075

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10.1101/GAD.543509

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17

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23

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Oscar Fernandez-Capetillo

Agueda M Tejera

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2009-08-13T00:00:00Z

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26740943

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19679647

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2751970

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