Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line
about
The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liverCellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissuesATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cellsEffect of P-glycoprotein on flavopiridol sensitivityIdentification and characterization of a gene that is coamplified with dihydrofolate reductase in a methotrexate-resistant CHO cell lineThe dihydrofolate reductase amplicons in different methotrexate-resistant Chinese hamster cell lines share at least a 273-kilobase core sequence, but the amplicons in some cell lines are much larger and are remarkably uniform in structure.Organization and genesis of dihydrofolate reductase amplicons in the genome of a methotrexate-resistant Chinese hamster ovary cell line.Transcripts from amplified sequences of an inherited homogeneously staining region in chromosome 1 of the house mouse (Mus musculus)Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell linesVincristine-resistant erythroleukemia cell line has marked increased sensitivity to hexamethylenebisacetamide-induced differentiation.The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.Isolation of the human anionic glutathione S-transferase cDNA and the relation of its gene expression to estrogen-receptor content in primary breast cancer.Isolation and characterization of Drosophila multidrug resistance gene homologs.A 22-kd protein (sorcin/V19) encoded by an amplified gene in multidrug-resistant cells, is homologous to the calcium-binding light chain of calpain.Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas.Pulsed-field electrophoresis: application of a computer model to the separation of large DNA molecules.Frequencies of independent and simultaneous selection of Chinese hamster cells for methotrexate and doxorubicin (adriamycin) resistanceExpression of a multidrug-resistance gene in human tumors and tissuesExpression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastinePre-clinical studies of a novel anti-mitotic agent, amphethinile.Expression of P-glycoprotein mRNA in human gastric tumors.Genetics of multidrug resistance.Cellular pharmacology of 4'-iodo-4'-deoxydoxorubicin.Reversal of intrinsic multidrug resistance in Chinese hamster ovary cells by amiloride analogsRegulation of P-glycoprotein gene expression in hepatocyte cultures and liver cell lines by a trans-acting transcriptional repressorDNA amplification in multidrug, cross-resistant Chinese hamster ovary cells: molecular characterization and cytogenetic localization of the amplified DNAP-glycoprotein structure and evolutionary homologies.Isolation of a human genomic fragment, co-amplified with c-Ki-ras, that affects plasmid supercoiling in E. coli.Overcoming multidrug resistance in Chinese hamster ovary cells in vitro by cyclosporin A (Sandimmune) and non-immunosuppressive derivatives.The transmission interface of the Saccharomyces cerevisiae multidrug transporter Pdr5: Val-656 located in intracellular loop 2 plays a major role in drug resistance.Chromosome breakage at a major fragile site associated with P-glycoprotein gene amplification in multidrug-resistant CHO cells.A possible role for a mammalian facilitative hexose transporter in the development of resistance to drugsPhysical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cellsStructure and expression of the human MDR (P-glycoprotein) gene family.Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia.Expression of hamster P-glycoprotein and multidrug resistance in DNA-mediated transformants of mouse LTA cells.Differential amplification and disproportionate expression of five genes in three multidrug-resistant Chinese hamster lung cell linesDecreased expression of the amplified mdr1 gene in revertants of multidrug-resistant human myelogenous leukemia K562 occurs without loss of amplified DNA.Double minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cellsSimilar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats.
P2860
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P2860
Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line
description
1986 nî lūn-bûn
@nan
1986 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1986 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
name
Overexpression and amplificati ...... hinese hamster ovary cell line
@ast
Overexpression and amplificati ...... hinese hamster ovary cell line
@en
type
label
Overexpression and amplificati ...... hinese hamster ovary cell line
@ast
Overexpression and amplificati ...... hinese hamster ovary cell line
@en
prefLabel
Overexpression and amplificati ...... hinese hamster ovary cell line
@ast
Overexpression and amplificati ...... hinese hamster ovary cell line
@en
P2093
P2860
P1476
Overexpression and amplificati ...... hinese hamster ovary cell line
@en
P2093
A M Van der Bliek
T Van der Velde-Koerts
P2860
P304
P407
P577
1986-05-01T00:00:00Z