The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells
about
The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathwaysB cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1Epstein-Barr virus latent membrane protein 2A (LMP2A) employs the SLP-65 signaling moduleAssociation of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alphaThe adaptor protein BLNK is required for b cell antigen receptor-induced activation of nuclear factor-kappa B and cell cycle entry and survival of B lymphocytesHematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytesSLP-65 phosphorylation dynamics reveals a functional basis for signal integration by receptor-proximal adaptor proteinsThe c-Rel transcription factor and B-cell proliferation: a deal with the devilSLP76 and SLP65: complex regulation of signalling in lymphocytes and beyondA leucine zipper in the N terminus confers membrane association to SLP-65Four tyrosine residues in phospholipase C-gamma 2, identified as Btk-dependent phosphorylation sites, are required for B cell antigen receptor-coupled calcium signalingIncreased numbers of B-1 cells and enhanced responses against TI-2 antigen in mice lacking APS, an adaptor molecule containing PH and SH2 domainsMIST functions through distinct domains in immunoreceptor signaling in the presence and absence of LAT.The adaptor protein Shc plays a key role during early B cell developmentInvolvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membraneSynergistic regulation of immunoreceptor signaling by SLP-76-related adaptor Clnk and serine/threonine protein kinase HPK-1.Identification of CMTM7 as a transmembrane linker of BLNK and the B-cell receptorMultitasking of Ig-alpha and Ig-beta to regulate B cell antigen receptor function.Regulation of phospholipase C-gamma2 and phosphoinositide 3-kinase pathways by adaptor proteins in B lymphocytes.The effects of the Epstein-Barr virus latent membrane protein 2A on B cell function.Adaptors as central mediators of signal transduction in immune cells.Regulation of activation and recombination of the murine Igkappa locus.Transmembrane adaptor proteins: organizers of immunoreceptor signalling.The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire.A B cell receptor with two Igalpha cytoplasmic domains supports development of mature but anergic B cells.Ca(2+) signaling in antigen receptor-activated B lymphocytes.BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function.Receptor crosstalk: reprogramming B cell receptor signalling to an alternate pathway results in expression and secretion of the autoimmunity-associated cytokine, osteopontinIncreased BCR responsiveness in B cells from patients with chronic GVHD.The molecular requirements for LAT-mediated differentiation and the role of LAT in limiting pre-B cell expansion.Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells.Identification and characterization of a novel BASH N terminus-associated protein, BNAS2.Novel Innate Immune Genes Regulating the Macrophage Response to Gram Positive BacteriaDeficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia.BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation.Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells.Delayed cellular maturation and decreased immunoglobulin kappa light chain production in immature B lymphocytes lacking B cell linker protein.Autonomous membrane IgE signaling prevents IgE-memory formation.
P2860
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P2860
The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells
description
2000 nî lūn-bûn
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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name
The B cell-restricted adaptor ...... mediated activation of B cells
@ast
The B cell-restricted adaptor ...... mediated activation of B cells
@en
type
label
The B cell-restricted adaptor ...... mediated activation of B cells
@ast
The B cell-restricted adaptor ...... mediated activation of B cells
@en
prefLabel
The B cell-restricted adaptor ...... mediated activation of B cells
@ast
The B cell-restricted adaptor ...... mediated activation of B cells
@en
P2093
P2860
P356
P1476
The B cell-restricted adaptor ...... mediated activation of B cells
@en
P2093
Goitsuka R
Kitamura D
P2860
P304
P356
10.1073/PNAS.040575697
P407
P577
2000-03-01T00:00:00Z