Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up.
about
Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processesNiemann-pick disease type C: implications for sedation and anesthesia for diagnostic proceduresCross-talk of membrane lipids and Alzheimer-related proteins.Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer's disease-linked presenilin 1 A246E mutation can be reversed with cAMPMicroarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression.Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.Altered levels and distribution of amyloid precursor protein and its processing enzymes in Niemann-Pick type C1-deficient mouse brainsLys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's diseaseAlterations in gene expression in mutant amyloid precursor protein transgenic mice lacking Niemann-Pick type C1 proteinElevation in sphingomyelin synthase activity is associated with increases in amyloid-beta peptide generation.Autophagy failure in Alzheimer's disease--locating the primary defect.Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease.Subcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice.Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease.Linking lipids to Alzheimer's disease: cholesterol and beyond.Cholinergic abnormalities, endosomal alterations and up-regulation of nerve growth factor signaling in Niemann-Pick type C disease.The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy.Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer diseaseAlzheimer's disease and cholesterol: the fat connection.Preventive and therapeutic effects of MG132 by activating Nrf2-ARE signaling pathway on oxidative stress-induced cardiovascular and renal injuryInhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects.Variation in NPC1, the gene encoding Niemann-Pick C1, a protein involved in intracellular cholesterol transport, is associated with Alzheimer disease and/or aging in the Polish population.Medical bioremediation of age-related diseases.Neuronal gene repression in Niemann-Pick type C models is mediated by the c-Abl/HDAC2 signaling pathway.Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis.Lysosomal proteomics and disease.Degradative proteomics and disease mechanisms.CNS regulation of plasma cholesterol.Reciprocal regulation of cholesterol and beta amyloid at the subcellular level in Alzheimer's disease.Role of endolysosomes and cholesterol in the pathogenesis of Alzheimer's disease: Insights into why statins might not provide clinical benefit.Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities.Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease.Cystatin C in aging and in Alzheimer's disease.Exacerbating and reversing lysosomal storage diseases: from yeast to humans.Multivariate profiling of neurodegeneration-associated changes in a subcellular compartment of neurons via image processingRole of LDL cholesterol and endolysosomes in amyloidogenesis and Alzheimer's disease.Altered Cholesterol Intracellular Trafficking and the Development of Pathological Hallmarks of Sporadic AD.
P2860
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P2860
Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up.
description
2004 nî lūn-bûn
@nan
2004 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մարտին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Niemann-Pick Type C disease an ...... ndosome connection fattens up.
@ast
Niemann-Pick Type C disease an ...... ndosome connection fattens up.
@en
type
label
Niemann-Pick Type C disease an ...... ndosome connection fattens up.
@ast
Niemann-Pick Type C disease an ...... ndosome connection fattens up.
@en
prefLabel
Niemann-Pick Type C disease an ...... ndosome connection fattens up.
@ast
Niemann-Pick Type C disease an ...... ndosome connection fattens up.
@en
P2860
P1476
Niemann-Pick Type C disease an ...... ndosome connection fattens up.
@en
P2093
Ralph A Nixon
P2860
P304
P356
10.1016/S0002-9440(10)63163-X
P407
P577
2004-03-01T00:00:00Z