Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates.
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JNK Signaling: Regulation and Functions Based on Complex Protein-Protein PartnershipsThe Pathogenesis of Nonalcoholic Fatty Liver Disease: Interplay between Diet, Gut Microbiota, and Genetic BackgroundResearch advances in the relationship between nonalcoholic fatty liver disease and atherosclerosisStress kinases in the modulation of metabolism and energy balanceMetabolic functions of FABPs--mechanisms and therapeutic implicationsMitochondrial dysfunction and tissue injury by alcohol, high fat, nonalcoholic substances and pathological conditions through post-translational protein modificationsOxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models?Guards and culprits in the endoplasmic reticulum: glucolipotoxicity and β-cell failure in type II diabetesOmega-3 Fatty Acids and FFAR4Free Fatty acids and their metabolism affect function and survival of podocytesRole of p62/SQSTM1 in liver physiology and pathogenesisFenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosisNatural history of β-cell adaptation and failure in type 2 diabetesDiabetic foot syndrome: Immune-inflammatory features as possible cardiovascular markers in diabetesChaperoning to the metabolic party: The emerging therapeutic role of heat-shock proteins in obesity and type 2 diabetesMolecular mechanisms of chromium in alleviating insulin resistanceA liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approachesJNK1 protects against glucolipotoxicity-mediated beta-cell apoptosisPalmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondriaCDK4 is an essential insulin effector in adipocytesSerine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cellsInsulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle.An islet in distress: β cell failure in type 2 diabetes.Role and mechanism of pancreatic β-cell death in diabetes: The emerging role of autophagy.Glucolipotoxicity of the pancreatic beta cell.PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver DiseasePeriostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPARα.Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated skeletal muscle insulin resistance.JNK regulation of hepatic manifestations of the metabolic syndrome.Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors.Alteration of JNK-1 signaling in skeletal muscle fails to affect glucose homeostasis and obesity-associated insulin resistance in miceLysophosphatidylcholine as an effector of fatty acid-induced insulin resistance.Cathepsin inhibition-induced lysosomal dysfunction enhances pancreatic beta-cell apoptosis in high glucoseThe chaperone balance hypothesis: the importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes, the effect of exercise, and the implications for clinical management.Human adipose cells in vitro are either refractory or responsive to insulin, reflecting host metabolic stateMaternal obesity promotes a proinflammatory signature in rat uterus and blastocyst.Serum Immunoglobulin M Concentration Varies with Triglyceride Levels in an Adult Population: Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIHealth) Cohort Study.Glucolipotoxicity in Pancreatic β-Cells.Vascular smooth muscle insulin resistance, but not hypertrophic signaling, is independent of angiotensin II-induced IRS-1 phosphorylation by JNKSaturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation.
P2860
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P2860
Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates.
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Saturated fatty acids inhibit ...... f insulin-receptor substrates.
@ast
Saturated fatty acids inhibit ...... f insulin-receptor substrates.
@en
type
label
Saturated fatty acids inhibit ...... f insulin-receptor substrates.
@ast
Saturated fatty acids inhibit ...... f insulin-receptor substrates.
@en
prefLabel
Saturated fatty acids inhibit ...... f insulin-receptor substrates.
@ast
Saturated fatty acids inhibit ...... f insulin-receptor substrates.
@en
P2093
P2860
P921
P356
P1476
Saturated fatty acids inhibit ...... f insulin-receptor substrates.
@en
P2093
Francesco Galimi
Giovanni Solinas
Myung-Shik Lee
Willscott Naugler
P2860
P304
16454-16459
P356
10.1073/PNAS.0607626103
P407
P577
2006-10-18T00:00:00Z