A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. - Wikidata - awgldk - TriplyDB

A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects.

A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects.

http://www.wikidata.org/entity/Q35149156

about

Reduced cholesterol and triglycerides in mice with a mutation in Mia2, a liver protein that localizes to ER exit sites Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids Phospholipid--driven gene regulation Orphan nuclear receptors and the regulation of nutrient metabolism: understanding obesity Energy metabolism in the liver Structural basis of coactivation of liver receptor homolog-1 by -catenin Divergent Sequence Tunes Ligand Sensitivity in Phospholipid-regulated Hormone Receptors Antidiabetic phospholipid–nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists Reveal a Novel Mechanism of Activation Hepatoprotectant ursodeoxycholyl lysophosphatidylethanolamide increasing phosphatidylcholine levels as a potential therapy of acute liver injury The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner.A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use.Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR.Mouse liver repopulation with hepatocytes generated from human fibroblasts.Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer The HR97 (NR1L) group of nuclear receptors: a new group of nuclear receptors discovered in Daphnia species.The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.Antiproliferation activity of a small molecule repressor of liver receptor homolog 1 Regeneration and repair of the exocrine pancreas.Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation.Haploinsufficiency for Stard7 is associated with enhanced allergic responses in lung and skin.Targeting orphan nuclear receptors for treatment of metabolic diseases and autoimmunity Nuclear receptor variants in liver disease.NR5A nuclear receptor Hr39 controls three-cell secretory unit formation in Drosophila female reproductive glands LRH-1-dependent glucose sensing determines intermediary metabolism in liver.Liver receptor homolog-1 (LRH-1): a potential therapeutic target for cancer Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket.Deficiency of multidrug resistance 2 contributes to cell transformation through oxidative stress.Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo.Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity.A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver.Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression.Nuclear receptors reverse McGarry's vicious cycle to insulin resistance.Minireview: the diverse roles of nuclear receptors in the regulation of embryonic stem cell pluripotency.Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese.Structure-based discovery of antagonists of nuclear receptor LRH-1.Idiopathic Hypogonadotropic Hypogonadism Caused by Inactivating Mutations in SRA1.KASL clinical practice guidelines: management of nonalcoholic fatty liver disease.

P2860

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P2860

A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects.

http://www.wikidata.org/entity/Q35149156

description

2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects.

@ast

A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects.

@en

type

label

A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects.

@ast

A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects.

@en

prefLabel

A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects.

@ast

A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects.

@en

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A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects.

@en

P2093

David D Moore

http://www.w3.org/2001/XMLSchema#string

Eric A Ortlund

http://www.w3.org/2001/XMLSchema#string

Jae Man Lee

http://www.w3.org/2001/XMLSchema#string

Jennifer L Mamrosh

http://www.w3.org/2001/XMLSchema#string

Manish C Pathak

http://www.w3.org/2001/XMLSchema#string

Patrick R Griffin

http://www.w3.org/2001/XMLSchema#string

Scott A Busby

http://www.w3.org/2001/XMLSchema#string

Yoon Kwang Lee

http://www.w3.org/2001/XMLSchema#string

P2860

Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP

Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17

Identification of a physiologically relevant endogenous ligand for PPARalpha in liver

Structure of SF-1 Bound by Different Phospholipids: Evidence for Regulatory Ligands

Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development.

Farnesoid X receptor is essential for normal glucose homeostasis

Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver.

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPARγ partial agonists

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

P2888

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506-510

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scholarly article

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10.1038/NATURE10111

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7352

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474

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2011-05-25T00:00:00Z

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51166626

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1022535361

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21614002

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1,2-dilauroyl-sn-glycero-3-phosphocholine

phosphatidylcholines

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3150801

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