Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer - Wikidata - awgldk - TriplyDB

Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer

Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer

http://www.wikidata.org/entity/Q35151491

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CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model Akt3 is responsible for the survival and proliferation of embryonic stem cells Follicular thyroid cancers demonstrate dual activation of PKA and mTOR as modeled by thyroid-specific deletion of Prkar1a and Pten in mice.Akt and phospholipase Cγ are involved in the regulation of growth and migration of MDA-MB-468 breast cancer and SW480 colon cancer cells when cultured with diabetogenic levels of glucose and insulin.Molecular pathogenesis and mechanisms of thyroid cancer Akt1 mediates neuronal differentiation in zebrafish via a reciprocal interaction with notch signaling Opposing functions of Akt isoforms in lung tumor initiation and progression Orthotopic mouse models for the preclinical and translational study of targeted therapies against metastatic human thyroid carcinoma with BRAF(V600E) or wild-type BRAF Mouse models of follicular and papillary thyroid cancer progression.Mouse models of thyroid cancer: A 2015 update.Prognosis of differentiated thyroid cancer in relation to serum thyrotropin and thyroglobulin antibody status at time of diagnosis.RCAN1-4 is a thyroid cancer growth and metastasis suppressor.Coupling of LETM1 up-regulation with oxidative phosphorylation and platelet-derived growth factor receptor signaling via YAP1 transactivation Genetics and epigenetics of sporadic thyroid cancer.BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models.Inhibition of breast cancer invasion by TIS21/BTG2/Pc3-Akt1-Sp1-Nox4 pathway targeting actin nucleators, mDia genes.Oncogene-induced senescence and its evasion in a mouse model of thyroid neoplasia.mTOR Pathway in Papillary Thyroid Carcinoma: Different Contributions of mTORC1 and mTORC2 Complexes for Tumor Behavior and SLC5A5 mRNA Expression.

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Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer

http://www.wikidata.org/entity/Q35151491

description

2011 nî lūn-bûn

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2011年の論文

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Akt1 deficiency delays tumor p ...... murine model of thyroid cancer

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Akt1 deficiency delays tumor p ...... murine model of thyroid cancer

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Akt1 deficiency delays tumor p ...... murine model of thyroid cancer

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Akt1 deficiency delays tumor p ...... murine model of thyroid cancer

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Akt1 deficiency delays tumor p ...... murine model of thyroid cancer

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Akt1 deficiency delays tumor p ...... murine model of thyroid cancer

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C Lu

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D Jarjoura

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K M La Perle

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P2860

Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions

RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.

Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolin

Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

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4307-4315

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scholarly article

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10.1038/ONC.2011.136

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42

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