Ligand-selective receptor conformations revisited: the promise and the problem.
about
Scalable rule-based modelling of allosteric proteins and biochemical networksHead-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model.Heteromerization of G protein-coupled receptors: relevance to neurological disorders and neurotherapeutics.The behavioral pharmacology of hallucinogensSome implications of receptor theory for in vivo assessment of agonists, antagonists and inverse agonistsA method for the prediction of GPCRs coupling specificity to G-proteins using refined profile Hidden Markov ModelsPhysiology of the orexinergic/hypocretinergic system: a revisit in 2012Non-traditional roles of G protein-coupled receptors in basic cell biologyThe sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticityUnderstanding functional residues of the cannabinoid CB1.OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanismsModifying ligand-induced and constitutive signaling of the human 5-HT4 receptorBihelix: Towards de novo structure prediction of an ensemble of G-protein coupled receptor conformations.Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding.Neuropharmacology of the naturally occurring kappa-opioid hallucinogen salvinorin AIdentifying conformational changes of the beta(2) adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulatorsBiasing the prostaglandin F2α receptor responses toward EGFR-dependent transactivation of MAPK.Normal mode analysis of biomolecular structures: functional mechanisms of membrane proteins.Ligand-directed signalling at beta-adrenoceptorsBinding of GTPgamma[35S] is regulated by GDP and receptor activation. Studies with the nociceptin/orphanin FQ receptor.Angiotensin II stimulates water and NaCl intake through separate cell signalling pathways in ratsSeven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Ligand-induced modulation of the free-energy landscape of G protein-coupled receptors explored by adaptive biasing techniquesEvidence for noncompetitive modulation of substrate-induced serotonin release.Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance.Theoretical considerations on the topological organization of receptor mosaicsLigand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization propertiesAction of molecular switches in GPCRs--theoretical and experimental studies.Dual signaling is differentially activated by different active states of the metabotropic glutamate receptor 1alphaFunctional selectivity in adrenergic and angiotensin signaling systems.Energy landscapes as a tool to integrate GPCR structure, dynamics, and function.Β-arrestin: a signaling molecule and potential therapeutic target for heart failure.Single-molecule force spectroscopy of G-protein-coupled receptors.Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process.Local peptide movement in the photoreaction intermediate of rhodopsin.Galpha encoding gene family of the malaria vector mosquito Anopheles gambiae: expression analysis and immunolocalization of AGalphaq and AGalphao in female antennaeThe evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology.A novel method for analyzing extremely biased agonism at G protein-coupled receptors.Differential activation of G-proteins by mu-opioid receptor agonists.Ensemble of G protein-coupled receptor active states.
P2860
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P2860
Ligand-selective receptor conformations revisited: the promise and the problem.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Ligand-selective receptor conformations revisited: the promise and the problem.
@ast
Ligand-selective receptor conformations revisited: the promise and the problem.
@en
type
label
Ligand-selective receptor conformations revisited: the promise and the problem.
@ast
Ligand-selective receptor conformations revisited: the promise and the problem.
@en
prefLabel
Ligand-selective receptor conformations revisited: the promise and the problem.
@ast
Ligand-selective receptor conformations revisited: the promise and the problem.
@en
P1476
Ligand-selective receptor conformations revisited: the promise and the problem.
@en
P2093
Terry Kenakin
P304
P356
10.1016/S0165-6147(03)00167-6
P577
2003-07-01T00:00:00Z