A chromatin insulator protects retrovirus vectors from chromosomal position effects. - Wikidata - awgldk - TriplyDB

A chromatin insulator protects retrovirus vectors from chromosomal position effects.

A chromatin insulator protects retrovirus vectors from chromosomal position effects.

http://www.wikidata.org/entity/Q35198059

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Transgenic nonhuman primates for neurodegenerative diseases Maintenance of integrated proviral gene expression requires Brm, a catalytic subunit of SWI/SNF complex The site of HIV-1 integration in the human genome determines basal transcriptional activity and response to Tat transactivation Lent-On-Plus Lentiviral vectors for conditional expression in human stem cells Shielding of sleeping beauty DNA transposon-delivered transgene cassettes by heterologous insulators in early embryonal cells Lineage analysis of the late otocyst stage mouse inner ear by transuterine microinjection of a retroviral vector encoding alkaline phosphatase and an oligonucleotide library.Read-through activation of transcription in a cellular genomic context Integrase-specific enhancement and suppression of retroviral DNA integration by compacted chromatin structure in vitro A look to future directions in gene therapy research for monogenic diseases.Comparison of insulators and promoters for expression of the Wiskott-Aldrich syndrome protein using lentiviral vectors.Incorporating double copies of a chromatin insulator into lentiviral vectors results in less viral integrants β-globin gene transfer to human bone marrow for sickle cell disease.Differences of globin transgene expression in stably transfected cell lines and transgenic mice.A functional screen for regulatory elements that improve retroviral vector gene expression Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator.Optimized lentiviral vector design improves titer and transgene expression of vectors containing the chicken beta-globin locus HS4 insulator element.Efficient entry inhibition of human and nonhuman primate immunodeficiency virus by cell surface-expressed gp41-derived peptides.BAC TG-EMBED: one-step method for high-level, copy-number-dependent, position-independent transgene expression.Immuno-therapy with anti-CTLA4 antibodies in tolerized and non-tolerized mouse tumor models.Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activities.The beta-globin locus control region versus gene therapy vectors: a struggle for expression.Gene therapy for genetic haematological disorders and immunodeficiencies.Silencing of gene expression: implications for design of retrovirus vectors.Poly(ADP-ribose) polymerase-1 (PARP-1) contributes to the barrier function of a vertebrate chromatin insulator.Genomic discovery of potent chromatin insulators for human gene therapy.The impact of cHS4 insulators on DNA transposon vector mobilization and silencing in retinal pigment epithelium cells.An Erythroid-Specific Chromatin Opening Element Increases β-Globin Gene Expression from Integrated Retroviral Gene Transfer Vectors.Globin gene transfer for the treatment of severe hemoglobinopathies: a paradigm for stem cell-based gene therapy.CpG island protects Rous sarcoma virus-derived vectors integrated into nonpermissive cells from DNA methylation and transcriptional suppression Controlled extracellular matrix degradation in breast cancer tumors improves therapy by trastuzumab Transcriptional control of erythropoiesis: emerging mechanisms and principles.Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs.Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy.Transdifferentiation and nuclear reprogramming in hematopoietic development and neoplasia.Identification and characterization of enhancer-blocking insulators to reduce retroviral vector genotoxicity Variegated expression from the murine band 3 (AE1) promoter in transgenic mice is associated with mRNA transcript initiation at upstream start sites and can be suppressed by the addition of the chicken beta-globin 5' HS4 insulator element.Occurrence of leukaemia following gene therapy of X-linked SCID.Current advances in retroviral gene therapy.Chromatin function modifying elements in an industrial antibody production platform--comparison of UCOE, MAR, STAR and cHS4 elements.An insulator element located at the cyclin B1 interacting protein 1 gene locus is highly conserved among mammalian species.

P2860

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P2860

A chromatin insulator protects retrovirus vectors from chromosomal position effects.

http://www.wikidata.org/entity/Q35198059

description

2000 nî lūn-bûn

@nan

2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2000年の論文

@ja

2000年論文

@yue

2000年論文

@zh-hant

2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

@wuu

name

A chromatin insulator protects retrovirus vectors from chromosomal position effects.

@ast

A chromatin insulator protects retrovirus vectors from chromosomal position effects.

@en

type

label

A chromatin insulator protects retrovirus vectors from chromosomal position effects.

@ast

A chromatin insulator protects retrovirus vectors from chromosomal position effects.

@en

prefLabel

A chromatin insulator protects retrovirus vectors from chromosomal position effects.

@ast

A chromatin insulator protects retrovirus vectors from chromosomal position effects.

@en

P1433

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P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

A chromatin insulator protects retrovirus vectors from chromosomal position effects.

@en

P2093

D W Emery

http://www.w3.org/2001/XMLSchema#string

E Yannaki

http://www.w3.org/2001/XMLSchema#string

G Stamatoyannopoulos

http://www.w3.org/2001/XMLSchema#string

J Tubb

http://www.w3.org/2001/XMLSchema#string

P2860

The protein CTCF is required for the enhancer blocking activity of vertebrate insulators

Improved retroviral vectors for gene transfer and expression.

Long-term expression of the gene encoding green fluorescent protein in murine hematopoietic cells using retroviral gene transfer.

Development of a high-titer retrovirus producer cell line capable of gene transfer into rhesus monkey hematopoietic stem cells.

Stopped at the border: boundaries and insulators.

Stem cell gene therapy for the beta-chain hemoglobinopathies. Problems and progress.

Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector.

An insulator element and condensed chromatin region separate the chicken beta-globin locus from an independently regulated erythroid-specific folate receptor gene

Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells

A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila.

P304

9150-9155

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P31

scholarly article

P356

10.1073/PNAS.160159597

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P407

P433

16

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P478

97

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P577

2000-08-01T00:00:00Z

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12410124

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10908661

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P932

16837

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