PML is induced by oncogenic ras and promotes premature senescence - Wikidata - awgldk - TriplyDB

PML is induced by oncogenic ras and promotes premature senescence

PML is induced by oncogenic ras and promotes premature senescence

http://www.wikidata.org/entity/Q35201220

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PML nuclear bodies Regulation of p53 activity in nuclear bodies by a specific PML isoform PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by Daxx MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex.PML colocalizes with and stabilizes the DNA damage response protein TopBP1 Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence MOZ increases p53 acetylation and premature senescence through its complex formation with PML ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging Molecular dissection of formation of senescence-associated heterochromatin foci The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells Old cells, new tricks: chromatin structure in senescence Markers of cellular senescence. Telomere shortening as a marker of cellular senescence The function, regulation and therapeutic implications of the tumor suppressor protein, PML The cell biology of disease: Acute promyelocytic leukemia, arsenic, and PML bodies Molecular mechanism of extrinsic factors affecting anti-aging of stem cells P53 mutations in colorectal cancer - molecular pathogenesis and pharmacological reactivation Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.Stem cells, senescence, neosis and self-renewal in cancer.Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells.Activation and activities of the p53 tumour suppressor protein Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor Adenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cells SnoN functions as a tumour suppressor by inducing premature senescence p63 deficiency activates a program of cellular senescence and leads to accelerated aging Pondering the puzzle of PML (promyelocytic leukemia) nuclear bodies: can we fit the pieces together using an RNA regulon?Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer Pondering the promyelocytic leukemia protein (PML) puzzle: possible functions for PML nuclear bodies.Characterization of the p53 response to oncogene-induced senescence.Knockdown of MBP-1 in human foreskin fibroblasts induces p53-p21 dependent senescence.Location of NLS-RARα protein in NB4 cell and nude mice.Tumor suppression by p53: making cells senescent.

P2860

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P2860

PML is induced by oncogenic ras and promotes premature senescence

http://www.wikidata.org/entity/Q35201220

description

2000 nî lūn-bûn

@nan

2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2000年の論文

@ja

2000年論文

@yue

2000年論文

@zh-hant

2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

@wuu

name

PML is induced by oncogenic ras and promotes premature senescence

@ast

PML is induced by oncogenic ras and promotes premature senescence

@en

type

label

PML is induced by oncogenic ras and promotes premature senescence

@ast

PML is induced by oncogenic ras and promotes premature senescence

@en

prefLabel

PML is induced by oncogenic ras and promotes premature senescence

@ast

PML is induced by oncogenic ras and promotes premature senescence

@en

P1433

Q35201220-6EEC4A9C-20D2-403D-A4DC-C5ABE8F3608E

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P2860

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P932

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P1433

Genes & Development

P1476

PML is induced by oncogenic ras and promotes premature senescence

@en

P2093

C Prives

http://www.w3.org/2001/XMLSchema#string

E de Stanchina

http://www.w3.org/2001/XMLSchema#string

G Ferbeyre

http://www.w3.org/2001/XMLSchema#string

N Baptiste

http://www.w3.org/2001/XMLSchema#string

S W Lowe

http://www.w3.org/2001/XMLSchema#string

P2860

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment

Binding and modulation of p53 by p300/CBP coactivators

PML, a growth suppressor disrupted in acute promyelocytic leukemia

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein

CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase

Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling

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2015-2027

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scholarly article

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16

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P478

14

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P50

Emmanuelle Querido

P577

2000-08-01T00:00:00Z

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P698

10950866

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P932

316863

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