Nucleotide-resolution mapping of topoisomerase-mediated and apoptotic DNA strand scissions at or near an MLL translocation hotspot
about
Leukemogenic rearrangements at the mixed lineage leukemia gene (MLL)-multiple rather than a single mechanismTDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivoThe benzene metabolite, hydroquinone and etoposide both induce endoreduplication in human lymphoblastoid TK6 cellsSignatures of selection in fusion transcripts resulting from chromosomal translocations in human cancerNext-generation sequencing of apoptotic DNA breakpoints reveals association with actively transcribed genes and gene translocations.Novel domain combinations in proteins encoded by chimeric transcriptsDynamics of double strand breaks and chromosomal translocationsModel for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity.Impact of Charged Particle Exposure on Homologous DNA Double-Strand Break Repair in Human Blood-Derived Cells.Etoposide sensitivity does not predict MLL rearrangements or risk of therapy-related acute myeloid leukemia.Estrogen treatment induces MLL aberrations in human lymphoblastoid cells.Rearrangements of the MLL gene are influenced by DNA secondary structure, potentially mediated by topoisomerase II binding.Topoisomerase II and leukemia.Mechanism of generation of therapy related leukemia in response to anti-topoisomerase II agents.Topoisomerase-mediated chromosomal break repair: an emerging player in many games.Estradiol induces gene proximity and MLL-MLLT3 fusion in an activation-induced cytidine deaminase-mediated pathway.Fluorescence-based recombination assay for sensitive and specific detection of genotoxic carcinogens in human cells.The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1.Multiple clonal MLL fusions in a patient receiving CHOP-based chemotherapy.Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine.Therapy-related acute myeloid leukemia following treatment with trabectedin for Ewing's sarcoma.Base excision repair proteins couple activation-induced cytidine deaminase and endonuclease G during replication stress-induced MLL destabilization.Endonuclease G initiates DNA rearrangements at the MLL breakpoint cluster upon replication stress.
P2860
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P2860
Nucleotide-resolution mapping of topoisomerase-mediated and apoptotic DNA strand scissions at or near an MLL translocation hotspot
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Nucleotide-resolution mapping ...... r an MLL translocation hotspot
@ast
Nucleotide-resolution mapping ...... r an MLL translocation hotspot
@en
type
label
Nucleotide-resolution mapping ...... r an MLL translocation hotspot
@ast
Nucleotide-resolution mapping ...... r an MLL translocation hotspot
@en
prefLabel
Nucleotide-resolution mapping ...... r an MLL translocation hotspot
@ast
Nucleotide-resolution mapping ...... r an MLL translocation hotspot
@en
P2093
P2860
P356
P1476
Nucleotide-resolution mapping ...... r an MLL translocation hotspot
@en
P2093
Alain Tremblay
Marc-Edouard Mirault
Patrick Boucher
P2860
P304
P356
10.1086/507791
P407
P577
2006-09-12T00:00:00Z