Nucleotide-resolution mapping of topoisomerase-mediated and apoptotic DNA strand scissions at or near an MLL translocation hotspot - Wikidata - awgldk - TriplyDB

Nucleotide-resolution mapping of topoisomerase-mediated and apoptotic DNA strand scissions at or near an MLL translocation hotspot

Nucleotide-resolution mapping of topoisomerase-mediated and apoptotic DNA strand scissions at or near an MLL translocation hotspot

http://www.wikidata.org/entity/Q35221459

about

Leukemogenic rearrangements at the mixed lineage leukemia gene (MLL)-multiple rather than a single mechanism TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo The benzene metabolite, hydroquinone and etoposide both induce endoreduplication in human lymphoblastoid TK6 cells Signatures of selection in fusion transcripts resulting from chromosomal translocations in human cancer Next-generation sequencing of apoptotic DNA breakpoints reveals association with actively transcribed genes and gene translocations.Novel domain combinations in proteins encoded by chimeric transcripts Dynamics of double strand breaks and chromosomal translocations Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity.Impact of Charged Particle Exposure on Homologous DNA Double-Strand Break Repair in Human Blood-Derived Cells.Etoposide sensitivity does not predict MLL rearrangements or risk of therapy-related acute myeloid leukemia.Estrogen treatment induces MLL aberrations in human lymphoblastoid cells.Rearrangements of the MLL gene are influenced by DNA secondary structure, potentially mediated by topoisomerase II binding.Topoisomerase II and leukemia.Mechanism of generation of therapy related leukemia in response to anti-topoisomerase II agents.Topoisomerase-mediated chromosomal break repair: an emerging player in many games.Estradiol induces gene proximity and MLL-MLLT3 fusion in an activation-induced cytidine deaminase-mediated pathway.Fluorescence-based recombination assay for sensitive and specific detection of genotoxic carcinogens in human cells.The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1.Multiple clonal MLL fusions in a patient receiving CHOP-based chemotherapy.Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine.Therapy-related acute myeloid leukemia following treatment with trabectedin for Ewing's sarcoma.Base excision repair proteins couple activation-induced cytidine deaminase and endonuclease G during replication stress-induced MLL destabilization.Endonuclease G initiates DNA rearrangements at the MLL breakpoint cluster upon replication stress.

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Nucleotide-resolution mapping of topoisomerase-mediated and apoptotic DNA strand scissions at or near an MLL translocation hotspot

http://www.wikidata.org/entity/Q35221459

description

2006 nî lūn-bûn

@nan

2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2006年の論文

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2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

Nucleotide-resolution mapping ...... r an MLL translocation hotspot

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Nucleotide-resolution mapping ...... r an MLL translocation hotspot

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type

label

Nucleotide-resolution mapping ...... r an MLL translocation hotspot

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Nucleotide-resolution mapping ...... r an MLL translocation hotspot

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prefLabel

Nucleotide-resolution mapping ...... r an MLL translocation hotspot

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Nucleotide-resolution mapping ...... r an MLL translocation hotspot

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American Journal of Human Genetics

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Nucleotide-resolution mapping ...... r an MLL translocation hotspot

@en

P2093

Alain Tremblay

http://www.w3.org/2001/XMLSchema#string

Marc-Edouard Mirault

http://www.w3.org/2001/XMLSchema#string

Patrick Boucher

http://www.w3.org/2001/XMLSchema#string

P2860

DNA topoisomerase IIalpha interacts with CAD nuclease and is involved in chromatin condensation during apoptotic execution

Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6.

Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family

MLL targets SET domain methyltransferase activity to Hox gene promoters

DNA topoisomerases

Diagnostic tool for the identification of MLL rearrangements including unknown partner genes

Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation

In vivo topoisomerase II cleavage of the Drosophila histone and satellite III repeats: DNA sequence and structural characteristics

Topoisomerase II inhibitor-related acute myeloid leukaemia.

Surviving apoptosis.

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779-791

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scholarly article

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10.1086/507791

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5

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2006-09-12T00:00:00Z

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6761261

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17033956

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apoptotic process

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1698565

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