Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits. - Wikidata - awgldk - TriplyDB

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits.

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits.

http://www.wikidata.org/entity/Q35234934

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Alzheimer mechanisms and therapeutic strategies Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model.Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.Neuropathological alterations in Alzheimer disease Presenilin-1 familial Alzheimer's disease mutation alters hippocampal neurogenesis and memory function in CCL2 null mice.The dendritic hypothesis for Alzheimer's disease pathophysiology.The role of mTOR signaling in Alzheimer disease Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models Cognitive Deficits, Changes in Synaptic Function, and Brain Pathology in a Mouse Model of Normal Aging(1,2,3).APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD).Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice.Arc regulates spine morphology and maintains network stability in vivo.Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network.Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease.Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model.Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.Fluoxetine induces input-specific hippocampal dendritic spine remodeling along the septotemporal axis in adulthood and middle age.Preclinical Assessment of Young Blood Plasma for Alzheimer Disease.Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: digital morphometric analyses Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life.Calcium-sensitive regulation of monoamine oxidase-A contributes to the production of peroxyradicals in hippocampal cultures: implications for Alzheimer disease-related pathology.Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs Epilepsy and cognitive impairments in Alzheimer disease Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease The Impact of Aging on Brain Pituitary Adenylate Cyclase Activating Polypeptide, Pathology and Cognition in Mice and Rhesus Macaques New insights on the role of microglia in synaptic pruning in health and disease Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice.Amyloid ion channels: a common structural link for protein-misfolding disease Aging-related changes in calcium-binding proteins in rat perirhinal cortex Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity.Crucial role of calbindin-D28k in the pathogenesis of Alzheimer's disease mouse model.Life extension factor klotho enhances cognition.

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Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits.

http://www.wikidata.org/entity/Q35234934

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Proceedings of the National Academy of Sciences of the United States of America

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Neuronal depletion of calcium- ...... se-related cognitive deficits.

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Brian Jones

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Gui-Qiu Yu

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Jacob Raber

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Jeannie Chin

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Jorge J Palop

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Lennart Mucke

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Lisa Kekonius

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P2860

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

Neuronal calcium signaling

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

Different data from different labs: lessons from studies of gene-environment interaction.

Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathophysiology.

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

Prospects for neurology and psychiatry.

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Alzheimer's disease

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170959

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