Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits.
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Alzheimer mechanisms and therapeutic strategiesInhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model.Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networksLevetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.Neuropathological alterations in Alzheimer diseasePresenilin-1 familial Alzheimer's disease mutation alters hippocampal neurogenesis and memory function in CCL2 null mice.The dendritic hypothesis for Alzheimer's disease pathophysiology.The role of mTOR signaling in Alzheimer diseasePhospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's diseaseThe autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease modelsCognitive Deficits, Changes in Synaptic Function, and Brain Pathology in a Mouse Model of Normal Aging(1,2,3).APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD).Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice.Arc regulates spine morphology and maintains network stability in vivo.Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network.Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor proteinEnkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease.Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-βGABA progenitors grafted into the adult epileptic brain control seizures and abnormal behaviorThe multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model.Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.Fluoxetine induces input-specific hippocampal dendritic spine remodeling along the septotemporal axis in adulthood and middle age.Preclinical Assessment of Young Blood Plasma for Alzheimer Disease.Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: digital morphometric analysesBiochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life.Calcium-sensitive regulation of monoamine oxidase-A contributes to the production of peroxyradicals in hippocampal cultures: implications for Alzheimer disease-related pathology.Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDsEpilepsy and cognitive impairments in Alzheimer diseaseNeuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's diseaseThe Impact of Aging on Brain Pituitary Adenylate Cyclase Activating Polypeptide, Pathology and Cognition in Mice and Rhesus MacaquesNew insights on the role of microglia in synaptic pruning in health and diseaseCatecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice.Amyloid ion channels: a common structural link for protein-misfolding diseaseAging-related changes in calcium-binding proteins in rat perirhinal cortexPharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin functionEarly induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity.Crucial role of calbindin-D28k in the pathogenesis of Alzheimer's disease mouse model.Life extension factor klotho enhances cognition.
P2860
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P2860
Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Neuronal depletion of calcium- ...... se-related cognitive deficits.
@ast
Neuronal depletion of calcium- ...... se-related cognitive deficits.
@en
type
label
Neuronal depletion of calcium- ...... se-related cognitive deficits.
@ast
Neuronal depletion of calcium- ...... se-related cognitive deficits.
@en
prefLabel
Neuronal depletion of calcium- ...... se-related cognitive deficits.
@ast
Neuronal depletion of calcium- ...... se-related cognitive deficits.
@en
P2093
P2860
P356
P1476
Neuronal depletion of calcium- ...... se-related cognitive deficits.
@en
P2093
Brian Jones
Gui-Qiu Yu
Jacob Raber
Jeannie Chin
Jorge J Palop
Lennart Mucke
Lisa Kekonius
P2860
P304
P356
10.1073/PNAS.1133381100
P407
P577
2003-07-24T00:00:00Z