Structural and functional domains of the Rous sarcoma virus transforming protein (pp60src)
about
Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activityA noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fpsTargeting of Moloney murine leukemia virus gag precursor to the site of virus buddingDetection of phosphotyrosine-containing proteins in the detergent-insoluble fraction of RSV-transformed fibroblasts by azobenzene phosphonate antibodiesLipid binding by the Unique and SH3 domains of c-Src suggests a new regulatory mechanism.SH3 domains specifically regulate kinase activity of expressed Src family proteins.Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src.Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.Specific proteolytic fragmentation of p60v-src in transformed cell lysates.Amino acid alterations within a highly conserved region of the Rous sarcoma virus src gene product pp60src inactivate tyrosine protein kinase activity.Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stabilityInhibition of the tyrosine kinase activity of v-src, v-fgr, and v-yes gene products by a monoclonal antibody which binds both amino and carboxy peptide fragments of pp60v-src.Site-directed point mutation in the src gene oF rous sarcoma virus results in an inactive src gene product.Site-directed mutagenesis of the src gene of Rous sarcoma virus: construction and characterization of a deletion mutant temperature sensitive for transformation.The complex of polyoma virus middle-T antigen and pp60c-src.Molecular genetic characterization of the mRNA coding for an inducible suppressor factor specific for L-glutamic acid60-L-alanine30-L-tyrosine10.Human cellular src gene: nucleotide sequence and derived amino acid sequence of the region coding for the carboxy-terminal two-thirds of pp60c-srcThe src protein contains multiple domains for specific attachment to membranes.Platelet-derived growth factor. Structure, function, and roles in normal and transformed cells.Activation of the transforming potential of p60c-src by a single amino acid changeTwo divergent cellular src genes are expressed in Xenopus laevis.Discrete primary locations of a tyrosine-protein kinase and of three proteins that contain phosphotyrosine in virally transformed chick fibroblastsNucleotide sequence of the feline retroviral oncogene v-fms shows unexpected homology with oncogenes encoding tyrosine-specific protein kinases.Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase.Platelet-derived growth factor stimulates tyrosine-specific protein kinase activity in Swiss mouse 3T3 cell membranes.Phospholipids stimulate phosphorylation of vinculin by the tyrosine-specific protein kinase of Rous sarcoma virusTransit of pp60v-src to the plasma membrane.Isolation and structural mapping of a human c-src gene homologous to the transforming gene (v-src) of Rous sarcoma virusMyristylation site in Pr65gag is essential for virus particle formation by Moloney murine leukemia virusActivation of the proto-oncogene p60c-src by point mutations in the SH2 domain.Structural differences between repressed and derepressed forms of p60c-srcThe common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase function.Deletions within the amino-terminal half of the c-src gene product that alter the functional activity of the protein.v-src mutations outside the carboxyl-coding region are not sufficient to fully activate transformation by pp60c-src in NIH 3T3 cells.Two independent mutations are required for temperature-sensitive cell transformation by a Rous sarcoma virus temperature-sensitive mutantGenetic analysis of p60v-src domains involved in the induction of different cell transformation parameters.The membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation.Morphf mutants of Rous sarcoma virus: nucleotide sequencing analysis suggests that a class of morphf mutants was generated through splicing of a cryptic intron.Creation of a chimeric oncogene: analysis of the biochemical and biological properties of v-erbB/src fusion polypeptideProcessing of p60v-src to its myristylated membrane-bound form
P2860
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P2860
Structural and functional domains of the Rous sarcoma virus transforming protein (pp60src)
description
1981 nî lūn-bûn
@nan
1981 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1981 թվականի մարտին հրատարակված գիտական հոդված
@hy
1981年の論文
@ja
1981年論文
@yue
1981年論文
@zh-hant
1981年論文
@zh-hk
1981年論文
@zh-mo
1981年論文
@zh-tw
1981年论文
@wuu
name
Structural and functional doma ...... transforming protein (pp60src)
@ast
Structural and functional doma ...... transforming protein (pp60src)
@en
type
label
Structural and functional doma ...... transforming protein (pp60src)
@ast
Structural and functional doma ...... transforming protein (pp60src)
@en
prefLabel
Structural and functional doma ...... transforming protein (pp60src)
@ast
Structural and functional doma ...... transforming protein (pp60src)
@en
P2860
P356
P1476
Structural and functional doma ...... transforming protein (pp60src)
@en
P2093
A D Levinson
S A Courtneidge
P2860
P304
P356
10.1073/PNAS.78.3.1624
P407
P577
1981-03-01T00:00:00Z