The common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase function.
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Closing in on the biological functions of Fps/Fes and FerIdentification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinasesTwo novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinaseThe cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors.SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchangeAssociation of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activityMultiple SH2-mediated interactions in v-src-transformed cells.Mutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinaseTyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOSStructural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activationProtein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating proteinInteractions of p62(dok) with p210(bcr-abl) and Bcr-Abl-associated proteins.The role of the Src homology domains in morphological transformation by v-srcThe nonreceptor protein-tyrosine kinase CSK complexes directly with the GTPase-activating protein-associated p62 protein in cells expressing v-Src or activated c-Src.En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase.Deletions in the SH2 domain of p60v-src prevent association with the detergent-insoluble cellular matrixSequence and functional differences between Schmidt-Ruppin D and Schmidt-Ruppin A strains of pp60v-srcSrc homology region 2 domains direct protein-protein interactions in signal transduction.Targeted disruption of the murine fps/fes proto-oncogene reveals that Fps/Fes kinase activity is dispensable for hematopoiesis.Mice devoid of fer protein-tyrosine kinase activity are viable and fertile but display reduced cortactin phosphorylation.Enhanced endotoxin sensitivity in fps/fes-null mice with minimal defects in hematopoietic homeostasis.Bimolecular fluorescence complementation demonstrates that the c-Fes protein-tyrosine kinase forms constitutive oligomers in living cells.Expression, purification and preliminary crystallographic studies on the catalytic region of the nonreceptor tyrosine kinase FesMammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response.Activation of the proto-oncogene p60c-src by point mutations in the SH2 domain.Delineation of functional determinants in the transforming protein of Fujinami sarcoma virus.Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.Structural requirements for enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptorsShc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinasesSecondary structure of Src homology 2 domain of c-Abl by heteronuclear NMR spectroscopy in solution.The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity.Inhibition of IL-6 family cytokines by SOCS3.Nonsense mutations in the C-terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours.Tyrosine phosphorylation of the Lyn Src homology 2 (SH2) domain modulates its binding affinity and specificity.The signal transduction mechanism responsible for gamma interferon-induced indoleamine 2,3-dioxygenase gene expression.Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylationTransformation of chicken embryo fibroblast cells by avian retroviruses containing the human Fyn gene and its mutated genes.Autophosphorylation of the Fes tyrosine kinase. Evidence for an intermolecular mechanism involving two kinase domain tyrosine residues.Disruption of coiled-coil domains in Fer protein-tyrosine kinase abolishes trimerization but not kinase activation.
P2860
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P2860
The common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase function.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
The common src homology region ...... -fps tyrosine kinase function.
@ast
The common src homology region ...... -fps tyrosine kinase function.
@en
type
label
The common src homology region ...... -fps tyrosine kinase function.
@ast
The common src homology region ...... -fps tyrosine kinase function.
@en
prefLabel
The common src homology region ...... -fps tyrosine kinase function.
@ast
The common src homology region ...... -fps tyrosine kinase function.
@en
P2093
P2860
P356
P1476
The common src homology region ...... -fps tyrosine kinase function.
@en
P2093
P2860
P304
P356
10.1128/MCB.9.10.4131
P407
P577
1989-10-01T00:00:00Z