Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91. - Wikidata - awgldk - TriplyDB

Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91.

Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91.

http://www.wikidata.org/entity/Q35470532

about

Structural aspects of calcium-release activated calcium channel function Permeation, selectivity and gating in store-operated CRAC channels The STIM1/Orai signaling machinery Molecular regulation of CRAC channels and their role in lymphocyte function Nanoscale patterning of STIM1 and Orai1 during store-operated Ca2+ entry Crystal Structure of the Calcium Release-Activated Calcium Channel Orai Calcium Dyshomeostasis in Tubular Aggregate Myopathy Diseases caused by mutations in ORAI1 and STIM1 Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA Stromal interaction molecule 1 (STIM1) and Orai1 mediate histamine-evoked calcium entry and nuclear factor of activated T-cells (NFAT) signaling in human umbilical vein endothelial cells.STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel.Molecular biophysics of Orai store-operated Ca2+ channels.Potent functional uncoupling between STIM1 and Orai1 by dimeric 2-aminodiphenyl borinate analogs.Store-operated calcium entry: Mechanisms and modulation.Critical role for Orai1 C-terminal domain and TM4 in CRAC channel gating.Insights into CRAC channel gating and ion permeation Store-operated Ca2+ Entry Mediated by Orai1 and TRPC1 Participates to Insulin Secretion in Rat β-Cells.Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle.Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation Orai3 TM3 point mutation G158C alters kinetics of 2-APB-induced gating by disulfide bridge formation with TM2 C101 Pore waters regulate ion permeation in a calcium release-activated calcium channel.A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca(2+) permeation and SOCE-induced gene transcription.Orai1-NFAT signalling pathway triggered by T cell receptor stimulation.Regulation of CRAC channels by protein interactions and post-translational modification.State-dependent block of Orai3 TM1 and TM3 cysteine mutants: insights into 2-APB activation.Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function.Structural and functional mechanisms of CRAC channel regulation.Orai channel pore properties and gating by STIM: implications from the Orai crystal structure.Molecular mechanisms of STIM/Orai communication.CRAC channel gating and its modulation by STIM1 and 2-aminoethoxydiphenyl borate.Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site.ORAI1 Mutations with Distinct Channel Gating Defects in Tubular Aggregate Myopathy.Pore opening mechanism of CRAC channels.Chansporter complexes in cell signaling.Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries.STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate.Membrane traffic research: challenges for the next decade.The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1.The Orai1 Store-operated Calcium Channel Functions as a Hexamer.Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N-terminus.

P2860

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P2860

Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91.

http://www.wikidata.org/entity/Q35470532

description

2011 nî lūn-bûn

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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年学术文章

@wuu

2011年学术文章

@zh-cn

2011年学术文章

@zh-hans

2011年学术文章

@zh-my

2011年学术文章

@zh-sg

2011年學術文章

@yue

name

Mutations in Orai1 transmembra ...... hannel closure at arginine 91.

@ast

Mutations in Orai1 transmembra ...... hannel closure at arginine 91.

@en

type

label

Mutations in Orai1 transmembra ...... hannel closure at arginine 91.

@ast

Mutations in Orai1 transmembra ...... hannel closure at arginine 91.

@en

prefLabel

Mutations in Orai1 transmembra ...... hannel closure at arginine 91.

@ast

Mutations in Orai1 transmembra ...... hannel closure at arginine 91.

@en

P1433

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P356

PNAS.1114821108

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Mutations in Orai1 transmembra ...... hannel closure at arginine 91.

@en

P2093

Andriy V Yeromin

http://www.w3.org/2001/XMLSchema#string

Anna Amcheslavsky

http://www.w3.org/2001/XMLSchema#string

Hongying Zheng

http://www.w3.org/2001/XMLSchema#string

Junjie Hu

http://www.w3.org/2001/XMLSchema#string

Michael D Cahalan

http://www.w3.org/2001/XMLSchema#string

Shenyuan L Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

Orai1 is an essential pore subunit of the CRAC channel

STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx

CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity

STIM1, an essential and conserved component of store-operated Ca2+ channel function

Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

Crystal structure and mechanism of a calcium-gated potassium channel

The crystal structure of a voltage-gated sodium channel

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10.1073/PNAS.1114821108

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P433

43

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P478

108

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2011-10-10T00:00:00Z

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51707334

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21987804

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P921

transmembrane protein

P932

3203763

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