Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia. - Wikidata - awgldk - TriplyDB

Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia.

Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia.

http://www.wikidata.org/entity/Q35553586

about

Mitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2 Cirmtuzumab inhibits Wnt5a-induced Rac1 activation in chronic lymphocytic leukemia treated with ibrutinib.The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model.A PI3K p110β-Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis.Functional Niche Competition Between Normal Hematopoietic Stem and Progenitor Cells and Myeloid Leukemia Cells Crosstalk between Bcl-2 family and Ras family small GTPases: potential cell fate regulation?Functions of BCL-X L at the Interface between Cell Death and Metabolism Rac1 modulates acute and subacute genotoxin-induced hepatic stress responses, fibrosis and liver aging Suppressive action of miRNAs to ARP2/3 complex reduces cell migration and proliferation via RAC isoforms in Hirschsprung disease Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo.In focus: MLL-rearranged leukemia.Mechanisms of mixed-lineage leukemia.Rho GTPases: Anti- or pro-neoplastic targets?Activation of Rac1 GTPase promotes leukemia cell chemotherapy resistance, quiescence and niche interaction.Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death.Rac1 promotes diethylnitrosamine (DEN)-induced formation of liver tumors.NF-κB: a coordinator for epigenetic regulation by MLL.HOX genes regulate Rac1 activity in hematopoietic cells through control of Vav2 expression.MLL-AF9-mediated immortalization of human hematopoietic cells along different lineages changes during ontogeny.Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines.BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells.The Rac GTPase in Cancer: From Old Concepts to New Paradigms.The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation.Rac1 is a novel therapeutic target in mantle cell lymphoma.Bruton's tyrosine kinase and RAC1 promote cell survival in MLL-rearranged acute myeloid leukemia.De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia.Cirmtuzumab inhibits ibrutinib-resistant, Wnt5a-induced Rac1 activation and proliferation in mantle cell lymphoma.Turning Stem Cells Bad: Generation of Clinically Relevant Models of Human Acute Myeloid Leukemia through Gene Delivery- or Genome Editing-Based Approaches

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P2860

Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia.

http://www.wikidata.org/entity/Q35553586

description

2011 nî lūn-bûn

@nan

2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Inhibition of Rac GTPase signa ...... d therapy in MLL-AF9 leukemia.

@ast

Inhibition of Rac GTPase signa ...... d therapy in MLL-AF9 leukemia.

@en

type

label

Inhibition of Rac GTPase signa ...... d therapy in MLL-AF9 leukemia.

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Inhibition of Rac GTPase signa ...... d therapy in MLL-AF9 leukemia.

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Inhibition of Rac GTPase signa ...... d therapy in MLL-AF9 leukemia.

@ast

Inhibition of Rac GTPase signa ...... d therapy in MLL-AF9 leukemia.

@en

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BLOOD-2011-04-351817

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P1476

Inhibition of Rac GTPase signa ...... d therapy in MLL-AF9 leukemia.

@en

P2093

Andrea Griesinger

http://www.w3.org/2001/XMLSchema#string

Ashish R Kumar

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Benjamin Mizukawa

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Chad E Harris

http://www.w3.org/2001/XMLSchema#string

David A Williams

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Fu-Sheng Chou

http://www.w3.org/2001/XMLSchema#string

James C Mulloy

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Junping Wei

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Mahesh Shrestha

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Mark Wunderlich

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P2860

A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

Characterization of RAC3, a novel member of the Rho family

Rho GTPases in hematopoiesis and hemopathies

Rho GTPases: biochemistry and biology

Modeling the initiation and progression of human acute leukemia in mice

Misguided transcriptional elongation causes mixed lineage leukemia

Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells

Rho and Rac take center stage

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5235-5245

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scholarly article

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10.1182/BLOOD-2011-04-351817

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21940819

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