SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines. - Wikidata - awgldk - TriplyDB

SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines.

SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines.

http://www.wikidata.org/entity/Q35570442

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An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells Intratumoral epiregulin is a marker of advanced disease in non-small cell lung cancer patients and confers invasive properties on EGFR-mutant cells Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab Identification of Biomarker and Co-Regulatory Motifs in Lung Adenocarcinoma Based on Differential Interactions Expression of aquaporin 5 (AQP5) promotes tumor invasion in human non small cell lung cancer.Src inhibitors act through different mechanisms in Non-Small Cell Lung Cancer models depending on EGFR and RAS mutational status.Aberrant trafficking of NSCLC-associated EGFR mutants through the endocytic recycling pathway promotes interaction with Src.Transcriptional profiling of non-small cell lung cancer cells with activating EGFR somatic mutations.Laser capture microdissection and protein microarray analysis of human non-small cell lung cancer: differential epidermal growth factor receptor (EGPR) phosphorylation events associated with mutated EGFR compared with wild type A phase II trial of the Src-kinase inhibitor saracatinib after four cycles of chemotherapy for patients with extensive stage small cell lung cancer: NCCTG trial N-0621.Src kinase-mediated phosphorylation stabilizes inducible nitric-oxide synthase in normal cells and cancer cells MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma.A chemical and phosphoproteomic characterization of dasatinib action in lung cancer PGE2/EP3/SRC signaling induces EGFR nuclear translocation and growth through EGFR ligands release in lung adenocarcinoma cells.Tyrosine phosphoproteomics identifies both codrivers and cotargeting strategies for T790M-related EGFR-TKI resistance in non-small cell lung cancer.A Phosphotyrosine Proteomic Screen Identifies Multiple Tyrosine Kinase Signaling Pathways Aberrantly Activated in Malignant Mesothelioma.SRC: a century of science brought to the clinic.Reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer.Locking Src/Abl Tyrosine Kinase Activities Regulate Cell Differentiation and Invasion of Human Cervical Cancer Cells Expressing E6/E7 Oncoproteins of High-Risk HPV Phase II study of dasatinib in patients with advanced non-small-cell lung cancer EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer.Lung injury and lung cancer caused by cigarette smoke-induced oxidative stress: Molecular mechanisms and therapeutic opportunities involving the ceramide-generating machinery and epidermal growth factor receptor.Phase I/II study of the Src inhibitor dasatinib in combination with erlotinib in advanced non-small-cell lung cancer.CD24 induces expression of the oncomir miR-21 via Src, and CD24 and Src are both post-transcriptionally downregulated by the tumor suppressor miR-34a.Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants.Tailoring tyrosine kinase inhibitors to fit the lung cancer genome.Chemoprevention of murine lung cancer by gefitinib in combination with prostacyclin synthase overexpression.The human immunodeficiency virus protease inhibitor ritonavir inhibits lung cancer cells, in part, by inhibition of survivin.Src mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cells Src family kinases and paclitaxel sensitivity.Rapamycin Enhances the Anti-Cancer Effect of Dasatinib by Suppressing Src/PI3K/mTOR Pathway in NSCLC Cells.Src regulates cigarette smoke-induced ceramide generation via neutral sphingomyelinase 2 in the airway epithelium The use of single-agent dasatinib in molecularly unselected non-small-cell lung cancer patients EGFR inhibition evokes innate drug resistance in lung cancer cells by preventing Akt activity and thus inactivating Ets-1 function A Phase I Study of Dasatinib with Concurrent Chemoradiation for Stage III Non-Small Cell Lung Cancer.Yes and Lyn play a role in nuclear translocation of the epidermal growth factor receptor.Rhodomycin A, a novel Src-targeted compound, can suppress lung cancer cell progression via modulating Src-related pathways.A large animal model to evaluate the effects of Hsp90 inhibitors for the treatment of lung adenocarcinoma.ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells

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SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines.

http://www.wikidata.org/entity/Q35570442

description

2007 nî lūn-bûn

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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SRC-family kinases are activat ...... receptor-dependent cell lines.

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SRC-family kinases are activat ...... receptor-dependent cell lines.

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SRC-family kinases are activat ...... receptor-dependent cell lines.

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SRC-family kinases are activat ...... receptor-dependent cell lines.

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SRC-family kinases are activat ...... receptor-dependent cell lines.

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SRC-family kinases are activat ...... receptor-dependent cell lines.

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The American Journal of Pathology

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SRC-family kinases are activat ...... receptor-dependent cell lines.

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Babita Saigal

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Faye M Johnson

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Jie Zhang

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Jonathan M Kurie

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Long Ma

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Marie Wislez

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Nishan Thilaganathan

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Shailaja Kalyankrishna

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Wei Wei

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P2860

Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alpha

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer.

Crystal structures of c-Src reveal features of its autoinhibitory mechanism

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Erlotinib in previously treated non-small-cell lung cancer

Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

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366-376

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1

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170

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Ignacio I Wistuba

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6601088

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