Core features of frontotemporal dementia recapitulated in progranulin knockout mice.
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Molecular Pathways Bridging Frontotemporal Lobar Degeneration and Psychiatric DisordersMechanisms of granulin deficiency: lessons from cellular and animal modelsMouse models of frontotemporal dementiaProgranulin: at the interface of neurodegenerative and metabolic diseasesThe disruption of Celf6, a gene identified by translational profiling of serotonergic neurons, results in autism-related behaviors.Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathologyEarly microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutationMicroglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged miceMotivational disturbances and effects of L-dopa administration in neurofibromatosis-1 model mice.Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathiesEffects of Exercise on Progranulin Levels and Gliosis in Progranulin-Insufficient MiceProgranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS.Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.Progranulin regulates neuronal outgrowth independent of sortilinInduced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects.Progranulin: an emerging target for FTLD therapies.Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonistsProgranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice.Early Cognitive/Social Deficits and Late Motor Phenotype in Conditional Wild-Type TDP-43 Transgenic Mice.FTD and ALS--translating mouse studies into clinical trials.Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia.Progranulin Deficiency Reduces CDK4/6/pRb Activation and Survival of Human Neuroblastoma SH-SY5Y Cells.ALS/FTLD: experimental models and reality.Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test.Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.Wild-type bone marrow transplant partially reverses neuroinflammation in progranulin-deficient mice.Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice.Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation.Human Central Nervous System (CNS) ApoE Isoforms Are Increased by Age, Differentially Altered by Amyloidosis, and Relative Amounts Reversed in the CNS Compared with Plasma.Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease.Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology.Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice
P2860
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P2860
Core features of frontotemporal dementia recapitulated in progranulin knockout mice.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Core features of frontotemporal dementia recapitulated in progranulin knockout mice.
@ast
Core features of frontotemporal dementia recapitulated in progranulin knockout mice.
@en
type
label
Core features of frontotemporal dementia recapitulated in progranulin knockout mice.
@ast
Core features of frontotemporal dementia recapitulated in progranulin knockout mice.
@en
prefLabel
Core features of frontotemporal dementia recapitulated in progranulin knockout mice.
@ast
Core features of frontotemporal dementia recapitulated in progranulin knockout mice.
@en
P2093
P2860
P1476
Core features of frontotemporal dementia recapitulated in progranulin knockout mice.
@en
P2093
D F Wozniak
J T Dearborn
N J Cairns
P2860
P304
P356
10.1016/J.NBD.2011.08.029
P577
2011-09-10T00:00:00Z