Core features of frontotemporal dementia recapitulated in progranulin knockout mice. - Wikidata - awgldk - TriplyDB

Core features of frontotemporal dementia recapitulated in progranulin knockout mice.

Core features of frontotemporal dementia recapitulated in progranulin knockout mice.

http://www.wikidata.org/entity/Q35577194

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Molecular Pathways Bridging Frontotemporal Lobar Degeneration and Psychiatric Disorders Mechanisms of granulin deficiency: lessons from cellular and animal models Mouse models of frontotemporal dementia Progranulin: at the interface of neurodegenerative and metabolic diseases The disruption of Celf6, a gene identified by translational profiling of serotonergic neurons, results in autism-related behaviors.Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice Motivational disturbances and effects of L-dopa administration in neurofibromatosis-1 model mice.Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathies Effects of Exercise on Progranulin Levels and Gliosis in Progranulin-Insufficient Mice Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS.Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.Progranulin regulates neuronal outgrowth independent of sortilin Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects.Progranulin: an emerging target for FTLD therapies.Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice.Early Cognitive/Social Deficits and Late Motor Phenotype in Conditional Wild-Type TDP-43 Transgenic Mice.FTD and ALS--translating mouse studies into clinical trials.Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia.Progranulin Deficiency Reduces CDK4/6/pRb Activation and Survival of Human Neuroblastoma SH-SY5Y Cells.ALS/FTLD: experimental models and reality.Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test.Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.Wild-type bone marrow transplant partially reverses neuroinflammation in progranulin-deficient mice.Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice.Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation.Human Central Nervous System (CNS) ApoE Isoforms Are Increased by Age, Differentially Altered by Amyloidosis, and Relative Amounts Reversed in the CNS Compared with Plasma.Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease.Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology.Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

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P2860

Core features of frontotemporal dementia recapitulated in progranulin knockout mice.

http://www.wikidata.org/entity/Q35577194

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2011 nî lūn-bûn

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name

Core features of frontotemporal dementia recapitulated in progranulin knockout mice.

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Core features of frontotemporal dementia recapitulated in progranulin knockout mice.

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type

label

Core features of frontotemporal dementia recapitulated in progranulin knockout mice.

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Core features of frontotemporal dementia recapitulated in progranulin knockout mice.

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prefLabel

Core features of frontotemporal dementia recapitulated in progranulin knockout mice.

@ast

Core features of frontotemporal dementia recapitulated in progranulin knockout mice.

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J.NBD.2011.08.029

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Neurobiology of Disease

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Core features of frontotemporal dementia recapitulated in progranulin knockout mice.

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D F Wozniak

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J T Dearborn

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N Ghoshal

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N J Cairns

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P2860

Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: an MRI study

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria

Development of a mouse test for repetitive, restricted behaviors: relevance to autism.

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration.

The impact of maternal separation on adult mouse behaviour and on the total neuron number in the mouse hippocampus.

Mice lacking the immediate early gene Egr3 respond to the anti-aggressive effects of clozapine yet are relatively resistant to its sedating effects.

HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

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10.1016/J.NBD.2011.08.029

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