Progranulin regulates neuronal outgrowth independent of sortilin - Wikidata - awgldk - TriplyDB

Progranulin regulates neuronal outgrowth independent of sortilin

Progranulin regulates neuronal outgrowth independent of sortilin

http://www.wikidata.org/entity/Q36430434

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Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains Mechanisms of granulin deficiency: lessons from cellular and animal models Therapeutic and diagnostic challenges for frontotemporal dementia Progranulin: at the interface of neurodegenerative and metabolic diseases Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation.Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress.Progranulin gene delivery protects dopaminergic neurons in a mouse model of Parkinson's disease.Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.Progranulin and Its Related MicroRNAs after Status Epilepticus: Possible Mechanisms of Neuroprotection.Insights into the role of progranulin in immunity, infection, and inflammation.Missense mutations in progranulin gene associated with frontotemporal lobar degeneration: study of pathogenetic features Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.Learning and memory with neuropathic pain: impact of old age and progranulin deficiency.Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling.Progranulin deficiency promotes post-ischemic blood-brain barrier disruption EphA2 is a functional receptor for the growth factor progranulin.Imbalance between TNFα and progranulin contributes to memory impairment and anxiety in sleep-deprived mice.Characterization of Regenerative Phenotype of Unrestricted Somatic Stem Cells (USSC) from Human Umbilical Cord Blood (hUCB) by Functional Secretome Analysis.The lysosomal protein cathepsin L is a progranulin protease.Progranulin, lysosomal regulation and neurodegenerative disease.The Receptor-interacting Serine/Threonine Protein Kinase 1 (RIPK1) Regulates Progranulin Levels.Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy.Genetics of FTLD: overview and what else we can expect from genetic studies.Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.Prosaposin is a regulator of progranulin levels and oligomerization.Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia.Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia.Novel progranulin variants do not disrupt progranulin secretion and cleavage.Reduced Tau protein expression is associated with frontotemporal degeneration with progranulin mutation.Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test.Progranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer's disease.Reduced miR-659-3p Levels Correlate with Progranulin Increase in Hypoxic Conditions: Implications for Frontotemporal Dementia Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer's Disease.The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels.Wild-type bone marrow transplant partially reverses neuroinflammation in progranulin-deficient mice.TMEM106B and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in Han Chinese.Disease and Region Specificity of Granulin Immunopositivities in Alzheimer Disease and Frontotemporal Lobar Degeneration.Elevated progranulin contributes to synaptic and learning deficit due to loss of fragile X mental retardation protein.

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Progranulin regulates neuronal outgrowth independent of sortilin

http://www.wikidata.org/entity/Q36430434

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2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

Progranulin regulates neuronal outgrowth independent of sortilin

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Progranulin regulates neuronal outgrowth independent of sortilin

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type

label

Progranulin regulates neuronal outgrowth independent of sortilin

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Progranulin regulates neuronal outgrowth independent of sortilin

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prefLabel

Progranulin regulates neuronal outgrowth independent of sortilin

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Progranulin regulates neuronal outgrowth independent of sortilin

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Molecular Neurodegeneration

P1476

Progranulin regulates neuronal outgrowth independent of sortilin

@en

P2093

Anders Nykjær

http://www.w3.org/2001/XMLSchema#string

Caroline Stetler

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Casey Cook

http://www.w3.org/2001/XMLSchema#string

Christopher D Link

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Jada Lewis

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Jennifer Gass

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Karen Jansen-West

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Nicole Finch

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Wing C Lee

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P2860

Progranulin in frontotemporal lobar degeneration and neuroinflammation

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.

Structure and chromosomal location of the human granulin gene

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

The neuropathology and clinical phenotype of FTD with progranulin mutations

Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

Progranulin deficiency decreases gross neural connectivity but enhances transmission at individual synapses

Neurotrophins and their receptors: a convergence point for many signalling pathways

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10.1186/1750-1326-7-33

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7

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Rosa Rademakers

Leonard Petrucelli

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2012-07-10T00:00:00Z

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229064238

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1036552711

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22781549

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3508877

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