Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.
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Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domainsThe role of progranulin in diabetes and kidney diseaseTherapeutic and diagnostic challenges for frontotemporal dementiaProgranulin: at the interface of neurodegenerative and metabolic diseasesFUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damageMicroglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.Progranulin and a five transmembrane domain-containing receptor-like gene are the key components in receptor activator of nuclear factor κB (RANK)-dependent formation of multinucleated osteoclastsProgranulin-derived Atsttrin directly binds to TNFRSF25 (DR3) and inhibits TNF-like ligand 1A (TL1A) activity.Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner.Progranulin promotes colorectal cancer proliferation and angiogenesis through TNFR2/Akt and ERK signaling pathways.Signaling Pathway of GP88 (Progranulin) in Breast Cancer Cells: Upregulation and Phosphorylation of c-myc by GP88/Progranulin in Her2-Overexpressing Breast Cancer CellsEndogenous growth factor stimulation of hemocyte proliferation induces resistance to Schistosoma mansoni challenge in the snail hostMacrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis.Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers.Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling.EphA2 is a functional receptor for the growth factor progranulin.Progranulin antibodies entertain a proinflammatory environment in a subgroup of patients with psoriatic arthritis.New discovery rarely runs smooth: an update on progranulin/TNFR interactionsProgranulin, lysosomal regulation and neurodegenerative disease.Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations.Progranulin Inhibits Human T Lymphocyte Proliferation by Inducing the Formation of Regulatory T Lymphocytes.Progranulin promotes tumour necrosis factor-induced proliferation of suppressive mouse CD4⁺ Foxp3⁺ regulatory T cells.Progranulin does not inhibit TNF and lymphotoxin-α signalling through TNF receptor 1.Proinflammatory progranulin antibodies in inflammatory bowel diseases.Elevated progranulin contributes to synaptic and learning deficit due to loss of fragile X mental retardation protein.Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease.Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury.Lack of Evidence for a Direct Interaction of Progranulin and Tumor Necrosis Factor Receptor-1 and Tumor Necrosis Factor Receptor-2 From Cellular Binding Studies.Modulation of Regulatory T Cell Activity by TNF Receptor Type II-Targeting Pharmacological Agents.The lysosomal function of progranulin, a guardian against neurodegeneration
P2860
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P2860
Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Progranulin does not bind tumo ...... y in immune or neuronal cells.
@en
type
label
Progranulin does not bind tumo ...... y in immune or neuronal cells.
@en
prefLabel
Progranulin does not bind tumo ...... y in immune or neuronal cells.
@en
P2093
P2860
P50
P1476
Progranulin does not bind tumo ...... y in immune or neuronal cells.
@en
P2093
Basar Cenik
Georgia Taylor
Joachim Herz
Kathryn F Hudson
Kimberley Yu
Lauren H Martens
Phillip Yu
Qiudong Deng
Robert V Farese
P2860
P304
P356
10.1523/JNEUROSCI.5336-12.2013
P407
P577
2013-05-01T00:00:00Z